Simmer K, Iles C A, James C, Thompson R P
Am J Clin Nutr. 1987 Jan;45(1):122-5. doi: 10.1093/ajcn/45.1.122.
Zinc absorption during pregnancy was measured before and 24 h after 2 wk of daily, oral, iron-folate supplements. Absorption was reduced 24 h after iron-folate, which suggests a mucosal rather than a luminal effect. Also, zinc absorption in 10 healthy volunteers was reduced by folate supplements alone. Therefore, routine iron and folate supplementation may both have deleterious effects on zinc metabolism, especially during pregnancy when iron-folate supplements are often prescribed despite adequate dietary intakes of iron and folate but not of zinc.
在每日口服铁 - 叶酸补充剂2周之前和之后24小时，测量了孕期锌的吸收情况。铁 - 叶酸补充剂服用24小时后锌吸收减少，这表明是黏膜效应而非腔内效应。此外，仅叶酸补充剂就能降低10名健康志愿者的锌吸收。因此，常规补充铁和叶酸可能都会对锌代谢产生有害影响，尤其是在孕期，尽管铁和叶酸的膳食摄入量充足，但锌的摄入量不足时，仍经常开具铁 - 叶酸补充剂。
