Nguyen Phuong, Grajeda Ruben, Melgar Paul, Marcinkevage Jessica, Flores Rafael, Ramakrishnan Usha, Martorell Reynaldo
Nutrition and Health Sciences Program, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
J Nutr Metab. 2012;2012:216179. doi: 10.1155/2012/216179. Epub 2012 Jun 7.
Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effects were assessed by generalized linear regression. Baseline hemoglobin (Hb) concentration was 137.4 ± 15.5 g/L, 13% were anemic and 54% had zinc deficiency. Hb cconcentrations were similar by supplement type, but Hb concentrations improved significantly in anemic women at baseline (increase of 21.8 g/L). Mean percentage changes in serum ferritin were significantly higher in daily compared to weekly supplemented groups (86% versus 32%). The addition of zinc to IFA supplements had no significant impact on iron or zinc status. In conclusion, adding zinc to IFA supplements did not modify efficacy on iron status or improve zinc status, but daily supplementation was more efficacious than weekly in improving iron stores.
铁和锌在微量营养素补充剂中可能会相互作用，从而降低疗效。我们在一项针对459名危地马拉女性进行的随机对照试验中，研究了锌和铁联合补充的交互作用。四组接受了为期12周的补充：（1）每周补充铁和叶酸（IFA）；（2）每周补充IFA和30毫克锌；（3）每日补充IFA；（4）每日补充IFA和15毫克锌。通过广义线性回归评估效果。基线血红蛋白（Hb）浓度为137.4±15.5克/升，13%的人贫血，54%的人缺锌。不同补充剂类型的Hb浓度相似，但基线时贫血女性的Hb浓度显著改善（增加21.8克/升）。与每周补充组相比，每日补充组血清铁蛋白的平均百分比变化显著更高（86%对32%）。在IFA补充剂中添加锌对铁或锌状态没有显著影响。总之，在IFA补充剂中添加锌不会改变对铁状态的疗效，也不会改善锌状态，但每日补充在改善铁储备方面比每周补充更有效。
