Dieudonné Arnaud, Becker Stéphanie, Soares Miguel, Hollenbeck Claire, De Goltstein Marie-Christine, Vera Pierre, Santus Robin
Nuclear Medicine Department, Henri Becquerel Cancer Center, 76000, Rouen, France.
QuantIF-LITIS EA4108, University of Rouen, Rouen, France.
EJNMMI Res. 2023 Nov 23;13(1):101. doi: 10.1186/s13550-023-01051-9.
Radioembolization is one therapeutic option for the treatment of locally early-stage hepatocellular carcinoma. The aim of this study was to evaluate the distribution of Lipiodol® ultra-fluid and microspheres and to simulate their effectiveness with different beta emitters (Y, Re, P, Ho, I, and Lu) on VX2 tumors implanted in the liver of 30 New Zealand rabbits.
Twenty-three out of 30 rabbits had exploitable data: 14 in the group that received Lipiodol® ultra-fluid (group L), 6 in the group that received microspheres (group M), and 3 in the control group (group C). The histologic analysis showed that the Lipiodol® ultra-fluid distributes homogeneously in the tumor up to 12 days after injection. The X-ray μCT images showed that Lipiodol® ultra-fluid has a more distal penetration in the tumor than microspheres. The entropy (disorder of the system) in the L group was significantly higher than in the M group (4.06 vs 2.67, p = 0.01). Equivalent uniform biological effective doses (EUBED) for a tumor-absorbed dose of 100 Gy were greater in the L group but without statistical significance except for Lu (p = 0.03). The radionuclides ranking by EUBED (from high to low) was Y, Re, P, Ho, I, and Lu.
This study showed a higher ability of Lipiodol® ultra-fluid to penetrate the tumor that translated into a higher EUBED. This study confirms Y as a good candidate for radioembolization, although P, Ho, and Re can achieve similar results.
放射性栓塞是治疗局部早期肝细胞癌的一种治疗选择。本研究的目的是评估超液态碘化油和微球的分布情况，并模拟它们与不同β发射体（钇、铼、磷、钬、碘和镥）对植入30只新西兰兔肝脏的VX2肿瘤的有效性。
30只兔子中有23只获得了可利用的数据：接受超液态碘化油的组（L组）有14只，接受微球的组（M组）有6只，对照组（C组）有3只。组织学分析表明，超液态碘化油在注射后12天内均匀分布于肿瘤中。X射线μCT图像显示，超液态碘化油在肿瘤中的穿透深度比微球更深。L组的熵（系统无序度）显著高于M组（4.06对2.67，p = 0.01）。肿瘤吸收剂量为100 Gy时，L组的等效均匀生物有效剂量（EUBED）更大，但除镥外无统计学意义（p = 0.03）。按EUBED（从高到低）排列的放射性核素顺序为钇、铼、磷、钬、碘和镥。
本研究表明超液态碘化油穿透肿瘤的能力更强，这转化为更高的EUBED。本研究证实钇是放射性栓塞的良好候选者，尽管磷、钬和铼也能取得类似结果。
