Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, China.
School of Medical Devices, Shenyang Pharmaceutical University, Shenyang 110016, China.
Biomaterials. 2023 Dec;303:122391. doi: 10.1016/j.biomaterials.2023.122391. Epub 2023 Nov 15.
Reactive oxygen species (ROS) play a crucial role in regulating the metabolism of tumor growth, metastasis, death and other biological processes. ROS-based nanodynamic therapies (NDTs) are becoming attractive due to non-invasive, low side effects and tumor-specific advantages. NDTs have rapidly developed into numerous branches, such as photodynamic therapy, chemodynamic therapy, sonodynamic therapy and so on. However, the complexity of the tumor microenvironment and the limitations of existing sensitizers have greatly restricted the therapeutic effects of NDTs, which heavily rely on ROS levels. To address the limitations of NDTs, various strategies have been developed to increase ROS yield, which is an urgent aspect for the positive development of NDTs. In this review, the nanodynamic potentiation strategies in terms of unique properties and universalities of NDTs are comprehensively outlined. We mainly summarize the current dilemmas faced by each NDT and the respective solutions. Meanwhile, the NDTs universalities-based potentiation strategies and NDTs-based combined treatments are elaborated. Finally, we conclude with a discussion of the key issues and challenges faced in the development and clinical transformation of NDTs.
活性氧（ROS）在调节肿瘤生长、转移、死亡和其他生物学过程的代谢中起着至关重要的作用。基于 ROS 的纳米动力学疗法（NDT）由于具有非侵入性、低副作用和肿瘤特异性等优点，正变得越来越有吸引力。NDT 迅速发展成许多分支，如光动力疗法、化学动力学疗法、声动力疗法等。然而，肿瘤微环境的复杂性和现有敏化剂的局限性极大地限制了 NDT 的治疗效果，这严重依赖于 ROS 水平。为了解决 NDT 的局限性，已经开发了各种策略来增加 ROS 的产生，这是 NDT 积极发展的一个紧迫方面。在这篇综述中，我们全面概述了 NDT 在独特性质和通用性方面的纳米动力学增强策略。我们主要总结了每种 NDT 目前面临的困境及其各自的解决方案。同时，阐述了基于 NDT 通用性的增强策略和基于 NDT 的联合治疗。最后，我们讨论了 NDT 的开发和临床转化所面临的关键问题和挑战。
