Research Center of Nano Technology and Application Engineering, Dongguan Innovation Institute, Guangdong Medical University, Dongguan 523808, China.
Guangdong Key Laboratory of Nanomedicine, CAS-HK Joint Lab of Biomaterials, CAS Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, China.
Molecules. 2024 Oct 11;29(20):4828. doi: 10.3390/molecules29204828.
Dynamic tumor therapies (mainly including photodynamic therapy (PDT) and sonodynamic therapy (SDT)) offer new approaches to cancer treatment. They are often characterized by their noninvasive nature, high selectivity, and low toxicity. Sensitizers are crucial for dynamic therapy. Developing efficient sensitizers with good biocompatibility and controllability is an important aim in dynamic therapy. Porphyrins and metalloporphyrins attract great attention due to their excellent photophysical properties and low cytotoxicity under non-light. Compared to porphyrins, metalloporphyrins show greater potential for dynamic therapy due to their enhanced photochemical and photophysical properties after metal ions coordinate with porphyrin rings. This paper reviews some metalloporphyrin-based sensitizers used in photo/sonodynamic therapy and combined therapy. In addition, the probable challenges and bottlenecks in clinical translation are also discussed.
动态肿瘤治疗（主要包括光动力治疗（PDT）和声动力治疗（SDT））为癌症治疗提供了新的方法。它们通常具有非侵入性、高选择性和低毒性的特点。敏化剂对于动态治疗至关重要。开发具有良好生物相容性和可控性的高效敏化剂是动态治疗的一个重要目标。由于卟啉及其金属配合物在非光照下具有优异的光物理性质和低细胞毒性，因此引起了人们的极大关注。与卟啉相比，金属卟啉由于金属离子与卟啉环配位后其光化学和光物理性质增强，因此在动态治疗中显示出更大的潜力。本文综述了一些用于光/声动力治疗和联合治疗的基于金属卟啉的敏化剂。此外，还讨论了临床转化中可能存在的挑战和瓶颈。
