Department of Physics & Astronomy, Texas Christian University, Fort Worth, TX, USA.
Results Probl Cell Differ. 2024;71:345-370. doi: 10.1007/978-3-031-37936-9_17.
Many viruses have the ability to cause cells to fuse into large multi-nucleated cells, known as syncytia. While the existence of syncytia has long been known and its importance in helping spread viral infection within a host has been understood, few mathematical models have incorporated syncytia formation or examined its role in viral dynamics. This review examines mathematical models that have incorporated virus-mediated cell fusion and the insights they have provided on how syncytia can change the time course of an infection. While the modeling efforts are limited, they show promise in helping us understand the consequences of syncytia formation if future modeling efforts can be coupled with appropriate experimental efforts to help validate the models.
许多病毒具有使细胞融合成大多核细胞的能力，称为合胞体。虽然合胞体的存在早已为人所知，其在帮助病毒在宿主内传播方面的重要性也已被理解，但很少有数学模型将合胞体的形成纳入其中，也很少有模型研究其在病毒动力学中的作用。这篇综述检查了纳入病毒介导的细胞融合的数学模型，以及它们提供的关于合胞体如何改变感染时间进程的见解。虽然建模工作有限，但如果未来的建模工作能够与适当的实验努力相结合，帮助验证模型，它们有望帮助我们理解合胞体形成的后果。
