Niu Li-Na, Jiao Kai, Fang Ming, Chen Ji-Hua
State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shanxi Key Laboratory of Stomatology, School of Stomatology, Air Force Medical University, Xi,an 710032, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2021 Apr 1;39(2):129-135. doi: 10.7518/hxkq.2021.02.002.
Oral-maxillofacial hard tissue is the support of maxillofacial structure and appearance, and lays the foundation for functions of oral and maxillofacial system. Once the defect occurs, it will not only affect the physiological functions such as chewing and pronunciation, but also have a significant impact on the psychological and social life of patients. However, the self-repairing capability of the oral-maxillofacial hard tissue is pretty limited, in which case, substitute materials are required for tissue repair. A huge gap exists between the physical, chemical, structural characteristics of conventional substitute materials and those of human hard tissues, resulting in poor repair effect. Based on this, scholars simulated the process of biomineralization in the development of hard tissues, to improve the structure and function of materials through biomimetic mineralization technology and enhance the repair performance of materials. The current understanding of biomineralization theory and the construction of biomimetic repair technology is still in the stage of rapid development. In recent years, a mass of innovative studies are keeping emerging. In this review, the representative advances in the repair of oral-maxillofacial hard tissues of the past five years are reviewed.
口腔颌面部硬组织是颌面结构和外观的支撑，为口腔颌面部系统的功能奠定基础。一旦出现缺损，不仅会影响咀嚼和发音等生理功能，还会对患者的心理和社会生活产生重大影响。然而，口腔颌面部硬组织的自我修复能力相当有限，在这种情况下，组织修复需要替代材料。传统替代材料的物理、化学、结构特征与人体硬组织的这些特征之间存在巨大差距，导致修复效果不佳。基于此，学者们模拟硬组织发育过程中的生物矿化过程，通过仿生矿化技术改善材料的结构和功能，增强材料的修复性能。目前对生物矿化理论的认识和仿生修复技术的构建仍处于快速发展阶段。近年来，大量创新研究不断涌现。在这篇综述中，回顾了过去五年口腔颌面部硬组织修复方面的代表性进展。
