脂质-DNA折纸纤维的组装与光触发拆卸
Assembly and optically triggered disassembly of lipid-DNA origami fibers.
作者信息
Julin Sofia, Best Nadine, Anaya-Plaza Eduardo, Enlund Eeva, Linko Veikko, Kostiainen Mauri A
机构信息
Biohybrid Materials, Department of Bioproducts and Biosystems, Aalto University, 00076 Aalto, Finland.
Technische Universität Darmstadt, 64289 Darmstadt, Germany.
出版信息
Chem Commun (Camb). 2023 Dec 12;59(99):14701-14704. doi: 10.1039/d3cc04677j.
The co-assembly of lipids and other compounds has recently gained increasing interest. Here, we report the formation of stimuli-responsive lipid-DNA origami fibers through the electrostatic co-assembly of cationic lipids and 6-helix bundle (6HB) DNA origami. The photosensitive lipid degrades when exposed to UV-A light, which allows a photoinduced, controlled release of the 6HBs from the fibers. The presented complexation strategy may find uses in developing responsive nanomaterials for therapeutics.
脂质与其他化合物的共组装近来越来越受到关注。在此，我们报道了通过阳离子脂质与6-螺旋束（6HB）DNA折纸的静电共组装形成刺激响应性脂质-DNA折纸纤维。这种光敏脂质在紫外-A光照射下会降解，从而实现从纤维中光诱导可控释放6HB。所提出的复合策略可能在开发用于治疗的响应性纳米材料方面有应用。
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