Department of Organic Chemistry, Universidad Autónoma de Madrid (UAM), Calle Francisco Tomás y Valiente 7, 28049 Madrid, Spain.
Didactic Research Laboratory of Experimental Sciences and Supramolecular Chemistry (UR17ES01), University of Carthage, Faculty of Sciences Bizerte, Zarzouna, 7021 Bizerte, Tunis.
Bioconjug Chem. 2021 Jun 16;32(6):1123-1129. doi: 10.1021/acs.bioconjchem.1c00176. Epub 2021 May 24.
Design and synthesis of novel photosensitizer architectures is a key step toward new multifunctional molecular materials. Photoactive Janus-type molecules provide interesting building blocks for such systems by presenting two well-defined chemical functionalities that can be utilized orthogonally. Herein a multifunctional phthalocyanine is reported, bearing a bulky and positively charged moiety that hinders their aggregation while providing the ability to adhere on DNA origami nanostructures via reversible electrostatic interactions. On the other hand, triethylene glycol moieties render a water-soluble and chemically inert corona that can stabilize the structures. This approach provides insight into the molecular design and synthesis of Janus-type sensitizers that can be combined with biomolecules, rendering optically active biohybrids.
新型光敏剂结构的设计和合成是开发新型多功能分子材料的关键步骤。光活性的双面型分子通过呈现两种可正交利用的明确化学官能团，为这类体系提供了有趣的构建模块。本文报道了一种多功能酞菁，它带有庞大的正电荷基团，可阻碍其聚集，同时通过可逆静电相互作用使其能够附着在 DNA 折纸纳米结构上。另一方面，三乙二醇基团赋予了水溶性和化学惰性的冠，从而稳定了结构。这种方法为双面型敏化剂的分子设计和合成提供了思路，可将其与生物分子结合，形成具有光学活性的生物杂化材料。
