Li Ming, Lv Yifan, Wang Mingming, Zhang Yaying, Pan Zilai, Luo Yu, Zhang Haili, Wang Jing
Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Radiology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, China.
Diagnostics (Basel). 2023 Nov 8;13(22):3404. doi: 10.3390/diagnostics13223404.
Hemorrhagic transformation (HT) is one of the common complications in patients with acute ischemic stroke (AIS). This study aims to investigate the value of different thresholds of Tmax generated from perfusion-weighted MR imaging (PWI) and the apparent diffusion coefficient (ADC) value in the prediction of HT in AIS. A total of 156 AIS patients were enrolled in this study, with 55 patients in the HT group and 101 patients in non-HT group. The clinical baseline data and multi-parametric MRI findings were compared between HT and non-HT groups to identify indicators related to HT. The optimal parameters for predicting HT and the corresponding cutoff values were obtained using the receiver operating characteristic curve analysis of the volumes of ADC < 620 × 10 mm/s and Tmax > 6 s, 8 s, and 10 s. The results showed that the volumes of ADC < 620 × 10 mm/s and Tmax > 6 s, 8 s, and 10 s in the HT group were all significantly larger than that in the non-HT group and were all independent risk factors for HT. Early measurement of the volume of Tmax > 10 s had the highest value, with a cutoff lesion volume of 10.5 mL.
出血性转化（HT）是急性缺血性卒中（AIS）患者常见的并发症之一。本研究旨在探讨灌注加权磁共振成像（PWI）生成的不同Tmax阈值和表观扩散系数（ADC）值在预测AIS患者HT中的价值。本研究共纳入156例AIS患者，其中HT组55例，非HT组101例。比较HT组和非HT组的临床基线数据和多参数MRI结果，以确定与HT相关的指标。通过对ADC<620×10 mm/s和Tmax>6 s、8 s和10 s体积的受试者工作特征曲线分析，获得预测HT的最佳参数及相应的截断值。结果显示，HT组ADC<620×10 mm/s和Tmax>6 s、8 s和10 s的体积均显著大于非HT组，且均为HT的独立危险因素。早期测量Tmax>10 s的体积价值最高，截断病变体积为10.5 mL。
