Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Hepatobiliary and Pancreatic Surgery and Digestive Organ Transplantation of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Open and Key Laboratory of Hepatobiliary & Pancreatic Surgery and Digestive Organ Transplantation at Henan Universities, Zhengzhou 450052, China; Henan Key Laboratory of Digestive Organ Transplantation, Zhengzhou 450052, China.
Department of Obstetrics and Gynaecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 Henan, China.
Biomed Pharmacother. 2022 Jun;150:112971. doi: 10.1016/j.biopha.2022.112971. Epub 2022 Apr 18.
Long non-coding RNAs (lncRNAs) play important roles in the occurrence and progression of tumors. Extensive research has contributed to the current understanding of the critical roles played by lncRNAs in various cancers. LncRNA MIR4435-2HG has been found to be crucial in many cancers, such as breast, cervical, colorectal, and gastric cancer. Expression of MIR4435-2HG is generally upregulated in cancers and MIR4435-2HG participates in many biological functions through molecular mechanism of competitive endogenous RNA networks. This review profiles recent research findings on the expression, functions, mechanism, and clinical value of MIR4435-2HG in cancer, and serves as a reference for further MIR4435-2HG-related research and clinical trials.
长链非编码 RNA（lncRNA）在肿瘤的发生和发展中发挥着重要作用。大量研究有助于我们目前理解 lncRNA 在各种癌症中发挥的关键作用。lncRNA MIR4435-2HG 在许多癌症中都很关键，如乳腺癌、宫颈癌、结直肠癌和胃癌。MIR4435-2HG 的表达在癌症中通常上调，MIR4435-2HG 通过竞争性内源性 RNA 网络的分子机制参与许多生物学功能。本综述介绍了 MIR4435-2HG 在癌症中的表达、功能、机制和临床价值的最新研究发现，为进一步的 MIR4435-2HG 相关研究和临床试验提供参考。
