Dornelles Gustavo, Araújo Glauber R de S, Rodrigues Marcus, Alves Vinicius, Almeida-Paes Rodrigo, Frases Susana
Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro 21040-900, Brazil.
J Fungi (Basel). 2023 Nov 20;9(11):1124. doi: 10.3390/jof9111124.
Fungal infections are a global public health challenge, especially among immunocompromised patients. yeasts, such as , have emerged as opportunistic pathogens, but have received less attention than . This study aimed to characterize the polysaccharides of and compare them with those of , analyzing their clinical implications. Comprehensive physicochemical, mechanical, and ultrastructural analyses of polysaccharides from both species were performed, revealing correlations with virulence and pathogenicity. cells are surrounded by a capsule smaller than that produced by , but with similar polysaccharides. Those polysaccharides are also secreted by . Cross-reactivity with was observed in a diagnostic antigen test, using both and samples, highlighting the need for more reliable tests. Some strains exhibited virulence comparable to that of in an invertebrate experimental model (). This study contributes to a deeper understanding of yeast pathogenicity and virulence, highlighting the need for more accurate diagnostic tests to improve the differential diagnosis of infections caused by basidiomycetous yeasts.
真菌感染是一项全球性的公共卫生挑战，在免疫功能低下的患者中尤为如此。诸如[具体酵母名称1]等酵母已成为机会性病原体，但受到的关注比[具体酵母名称2]少。本研究旨在表征[具体酵母名称1]的多糖，并将其与[具体酵母名称2]的多糖进行比较，分析它们的临床意义。对这两种酵母的多糖进行了全面的物理化学、力学和超微结构分析，揭示了与毒力和致病性的相关性。[具体酵母名称1]细胞被一层比[具体酵母名称2]产生的更小的荚膜包围，但多糖相似。这些多糖也由[具体酵母名称2]分泌。在诊断性[具体抗原名称]抗原试验中，使用[具体酵母名称1]和[具体酵母名称2]的样本均观察到与[具体酵母名称2]的交叉反应，凸显了对更可靠检测方法的需求。在无脊椎动物实验模型（[具体模型名称]）中，一些[具体酵母名称1]菌株表现出与[具体酵母名称2]相当的毒力。本研究有助于更深入地了解酵母的致病性和毒力，强调需要更准确的诊断测试以改善担子菌酵母引起的感染的鉴别诊断。
