AlZain Mashail N, Albarakaty Fawziah M, El-Desoukey Rehab M A
Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, Riyadh 11451, Saudi Arabia.
Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah Al Mukarramah P.O. Box 715, Saudi Arabia.
Life (Basel). 2023 Nov 11;13(11):2197. doi: 10.3390/life13112197.
Due to the global issue of antimicrobial resistance, one of the most significant challenges in microbiological research is to develop a replacement antibiotic with minimal adverse effects. The wild shrub (gethgath) has been traditionally used for camel and ruminant grazing. While prior research has demonstrated its antimicrobial properties against human diseases, no investigations have been conducted on its efficacy against animal pathogens. The objective of this study is to explore the ethnobotanical, phytochemical, antioxidant, anticancer, and antimicrobial activity of aqueous and solvent extracts against a range of standard and animal pathogens. All of the extracts demonstrated antimicrobial, antioxidant, and anticancer properties, containing bioactive compounds. Notably, the ethyl acetate extract of exhibited the strongest antimicrobial activity against tested Gram-positive and Gram-negative bacteria and fungi. The chloroform fraction displayed the highest antioxidant activity. Additionally, the ethyl acetate fraction showed promising anticancer activity against breast (MCF-7) and lung (A549) cancer cells. These findings confirm that is a valuable shrub with potential applications as a natural alternative for antimicrobial, antioxidant, and anticancer treatments in both human and veterinary medicine.
由于全球抗菌药物耐药性问题，微生物研究中最重大的挑战之一是开发一种副作用最小的替代抗生素。野生灌木（gethgath）传统上用于骆驼和反刍动物放牧。虽然先前的研究已证明其对人类疾病具有抗菌特性，但尚未对其针对动物病原体的功效进行研究。本研究的目的是探索水提取物和溶剂提取物对一系列标准病原体和动物病原体的民族植物学、植物化学、抗氧化、抗癌及抗菌活性。所有提取物均表现出抗菌、抗氧化和抗癌特性，含有生物活性化合物。值得注意的是，该植物的乙酸乙酯提取物对测试的革兰氏阳性菌、革兰氏阴性菌和真菌表现出最强的抗菌活性。氯仿馏分显示出最高的抗氧化活性。此外，乙酸乙酯馏分对乳腺癌（MCF - 7）和肺癌（A549）细胞显示出有前景的抗癌活性。这些发现证实，该植物是一种有价值的灌木，在人类和兽医学中作为抗菌、抗氧化和抗癌治疗的天然替代品具有潜在应用价值。
