mitigates nephrotoxicity induced by carbon tetrachloride in rats regulation oxidative, inflammatory, tubular and glomerular indices.

CONTEXT

Carbon tetrachloride (CCl) induces oxidative stress in various tissues by altering antioxidants defense system. Recently, there has been a substantial use of phytotherapy to treat different diseases.

OBJECTIVE

This study was designed to evaluate the curative effect of (Forssk.) Benth et Hook (Family Asteraceae) aerial parts ethanol extract against CCl induced toxicity in rats kidneys.

MATERIALS AND METHODS

Nephrotoxicity was induced by intraperitoneal injection with CCl in a dose of 0.5 mL/kg b.wt./twice a week for six consecutive weeks. Serum kidney function tests, oxidative stress markers, inflammatory cytokines, nephrotoxicity biomarkers and histopathological observation were evaluated.

RESULTS

CCl increased serum kidney function parameters, malondialdehyde level, inflammatory cytokines, and nephrotoxicity markers, while decreased certain oxidative stress indices as superoxide dismutase and glutathione refereeing to the control group ( < 0.0001). Administration of ethanol extract to CCl injured rats attenuated these changes with variable degrees. The results were confirmed through the observed amelioration of the renal histological architectures.

CONCLUSION

ethanol extract possesses potent curative effect against CCl-induced nephropathy through improvement of kidney function, oxidative stress, inflammatory and nephrotoxicity index and the renal histopathological features. To establish the therapeutic and pharmacological applications of the plant, additional researches are required.