Buziková Michaela, Willimetz Robert, Kotek Jan
Department of Inorganic Chemistry, Charles University, Hlavova 2030, 128 40 Prague, Czech Republic.
Molecules. 2023 Nov 11;28(22):7542. doi: 10.3390/molecules28227542.
A set of substituted 1,4,7-triazacyclononane ligands was synthesised, including a wide series of novel derivatives bearing a thiazole or thiophene side group, with the potential to incorporate these derivatives into a polymeric material; some previously known/studied ligands were also synthesised for comparative purposes. The corresponding copper(II) complexes were prepared, and their ability to mediate the hydrolysis of phosphate ester bonds was studied via UV-Vis spectrophotometry, using bis(-nitrophenyl)phosphate as a model substrate. Some of the prepared complexes showed a considerable enhancement of the phosphate ester hydrolysis in comparison with previously studied systems, which makes them some of the most effective complexes ever tested for this purpose. Therefore, these novel, potentially bifunctional systems could provide the possibility of creating new coating materials for medicinal devices that could prevent biofilm formation.
合成了一组取代的1,4,7-三氮杂环壬烷配体，包括一系列带有噻唑或噻吩侧基的新型衍生物，这些衍生物有潜力被纳入聚合物材料中；还合成了一些先前已知/研究过的配体用于比较。制备了相应的铜（II）配合物，并以双（对硝基苯基）磷酸酯为模型底物，通过紫外可见分光光度法研究了它们介导磷酸酯键水解的能力。与先前研究的体系相比，一些制备的配合物显示出磷酸酯水解有显著增强，这使它们成为为此目的测试过的最有效的配合物之一。因此，这些新型的、潜在的双功能体系可能为制造可防止生物膜形成的医疗设备新型涂层材料提供可能性。
