Buziková Michaela, Zhukouskaya Hanna, Tomšík Elena, Vetrík Miroslav, Kučka Jan, Hrubý Martin, Kotek Jan
Department of Inorganic Chemistry, Charles University, Hlavova 8, 128 40 Prague, Czech Republic.
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, 162 06 Prague, Czech Republic.
Polymers (Basel). 2024 Oct 16;16(20):2911. doi: 10.3390/polym16202911.
Organophosphate neuroactive agents represent severe security threats in various scenarios, including military conflicts, terrorist activities and industrial accidents. Addressing these threats necessitates effective protective measures, with a focus on decontamination strategies. Adsorbents such as bentonite have been explored as a preliminary method for chemical warfare agent immobilization, albeit lacking chemical destruction capabilities. Chemical decontamination, on the other hand, involves converting these agents into non-toxic or less toxic forms. In this study, we investigated the hydrolytic activity of a Cu(II) complex, previously studied for phosphate ester hydrolysis, as a potential agent for chemical warfare decontamination. Specifically, we focused on a ligand featuring a thiophene anchor bound through an aliphatic spacer, which exhibited high hydrolytic activity in its Cu(II) complex form in our previous studies. Paraoxon, an efficient insecticide, was selected as a model substrate for hydrolytic studies due to its structural resemblance to specific chemical warfare agents and due to the presence of a chromogenic 4-nitrophenolate moiety. Our findings clearly show the hydrolytic activity of the studied Cu(II) complexes. Additionally, we demonstrate the immobilization of the studied complex onto a solid substrate of Amberlite XAD4 via copolymerization of its thiophene side group with dithiophene. The hydrolytic activity of the resultant material towards paraoxon was studied, indicating its potential utilization in organophosphate neuroactive agent decontamination under mild conditions and the key importance of surface adsorption of paraoxon on the polymer surface.
有机磷酸酯神经活性剂在包括军事冲突、恐怖活动和工业事故在内的各种场景中构成严重的安全威胁。应对这些威胁需要有效的防护措施，重点是去污策略。膨润土等吸附剂已被探索作为固定化学战剂的初步方法，尽管缺乏化学销毁能力。另一方面，化学去污涉及将这些药剂转化为无毒或毒性较小的形式。在本研究中，我们研究了一种先前用于磷酸酯水解研究的铜（II）配合物作为化学战去污潜在药剂的水解活性。具体而言，我们关注一种通过脂肪族间隔基连接噻吩锚定基团的配体，在我们先前的研究中，其铜（II）配合物形式表现出高水解活性。对氧磷，一种高效杀虫剂，因其结构与特定化学战剂相似且存在生色4-硝基酚盐部分，被选作水解研究的模型底物。我们的研究结果清楚地表明了所研究的铜（II）配合物的水解活性。此外，我们通过其噻吩侧基与二噻吩的共聚，证明了所研究的配合物固定在Amberlite XAD4固体基质上。研究了所得材料对氧磷的水解活性，表明其在温和条件下用于有机磷酸酯神经活性剂去污的潜力以及对氧磷在聚合物表面的表面吸附的关键重要性。
