精油作为有潜力的抗增殖、酪氨酸酶抑制和抗氧化候选物的研究进展。
Insights on Essential Oil as Potential Anti-Proliferative, Anti-Tyrosinase, and Antioxidant Candidate.
机构信息
Laboratory of Aromatic and Medicinal Plants, Center of Biotechnology of Borj-Cedria, BP 901, Hammam-Lif 2050, Tunisia.
Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis 1068, Tunisia.
出版信息
Molecules. 2023 Nov 11;28(22):7547. doi: 10.3390/molecules28227547.
In this study, the anti-cancer, anti-tyrosinase, and antioxidant activities of essential oils (EOs) of berries and leaves of grown wild in North of Tunisia were investigated. The EO yields from leaves and berries were 1.69% and 0.45%, respectively. GC-MS analysis revealed that α-pinene is the predominant component in both EOs (44.17 and 83.56%, respectively). Leaves essential oil presented high levels of β-phellandrene (18%) and camphene (15%). The EOs displayed cytotoxic effects against MCF-7 breast cancer cell, HT-29 colon cancer, and the normal cells H9C2 cardiomyoblasts. Leaves oil strongly inhibited colon cell line proliferation (IC of 38 µg/mL), while berries essential oil was more potent against breast cancerous cells MCF-7 (IC of 60 µg/mL). Interestingly, berries essential oil exhibited high ability to inhibit melanin synthesis by inhibiting enzyme mono and diphenolase activities. Overall, the results suggested that the two oils are significant sources of healthy natural chemicals.
本研究调查了突尼斯北部野生生长的浆果和叶片的精油（EOs）的抗癌、抗酪氨酸酶和抗氧化活性。叶片和浆果的 EO 得率分别为 1.69%和 0.45%。GC-MS 分析表明，α-蒎烯是两种 EO 中的主要成分（分别为 44.17%和 83.56%）。叶片精油中 β-水芹烯（18%）和莰烯（15%）含量较高。EOs 对 MCF-7 乳腺癌细胞、HT-29 结肠癌细胞和正常细胞 H9C2 心肌细胞表现出细胞毒性作用。叶片油强烈抑制结肠细胞系增殖（IC 为 38μg/mL），而浆果精油对乳腺癌细胞 MCF-7 的作用更强（IC 为 60μg/mL）。有趣的是，浆果精油表现出抑制黑色素合成的高能力，抑制单酚和二酚酶的活性。总的来说，这些结果表明，这两种油是健康天然化学物质的重要来源。
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