Shibata Haruko, Nakayama Moeko, Tagami Koto, Kanbara Tadashi, Yajima Tomoko
Department of Chemistry, Ochanomizu University, 2-1-1 Otsuka, Bukyo-ku, Tokyo 104-8610, Japan.
Molecules. 2023 Nov 14;28(22):7577. doi: 10.3390/molecules28227577.
Fluoroalkyl compounds are widely used, underscoring a pressing need for the development of methods for their synthesis. However, reports on perfluoroalkylation to styrenes have been sparse. In this study, both hydroxy- and hydro-perfluoroalkylation of styrene were achieved using visible light reactions, catalyzed by eosin Y, by selecting appropriate additives and controlling the eosin Y quenching cycle. These reactions are heavy-metal free, use water as the hydroxyl or hydrogen source, and employ inexpensive and readily available reagents.
氟代烷基化合物被广泛使用，这凸显了开发其合成方法的迫切需求。然而，关于苯乙烯全氟烷基化的报道却很少。在本研究中，通过选择合适的添加剂并控制曙红Y猝灭循环，利用曙红Y催化的可见光反应实现了苯乙烯的羟基和氢全氟烷基化。这些反应无重金属，以水作为羟基或氢源，并使用廉价且易于获得的试剂。
