College of Life Sciences, Qingdao University, Qingdao 266071, China.
Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266061, China.
Molecules. 2023 Nov 15;28(22):7610. doi: 10.3390/molecules28227610.
Hypertension is a common disease that affects human health and can lead to damage to the heart, kidneys, and other important organs. In this study, we investigated the regulatory effects of bioactive peptides derived from (RPP) on hypertension and organ protection in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. We found that RPPs exhibited significant blood pressure-lowering properties. Furthermore, the results showed that RPPs positively influenced vascular remodeling and effectively maintained a balanced water-sodium equilibrium. Meanwhile, RPPs demonstrated anti-inflammatory potential by reducing the serum levels of inflammatory cytokines (TNF-α, IL-2, and IL-6). Moreover, we observed the strong antioxidant activity of RPPs, which played a critical role in reducing oxidative stress and alleviating hypertension-induced damage to the aorta, heart, and kidneys. Additionally, our study explored the regulatory effects of RPPs on the gut microbiota, suggesting a possible correlation between their antihypertensive effects and the modulation of gut microbiota. Our previous studies have demonstrated that RPPs can significantly reduce blood pressure in SHR rats. This suggests that RPPs can significantly improve both essential hypertension and DOAC-salt-induced secondary hypertension and can ameliorate cardiorenal damage caused by hypertension. These findings further support the possibility of RPPs as an active ingredient in functional anti-hypertensive foods.
高血压是一种常见的疾病，会影响人类健康，并可能导致心脏、肾脏和其他重要器官受损。在这项研究中，我们研究了来源于（RPP）的生物活性肽对去氧皮质酮醋酸盐（DOCA）-盐高血压大鼠的高血压和器官保护的调节作用。我们发现 RPP 具有显著的降血压特性。此外，结果表明 RPP 对血管重塑有积极影响，并有效地维持了水钠平衡。同时，RPP 通过降低血清中炎症细胞因子（TNF-α、IL-2 和 IL-6）的水平表现出抗炎潜力。此外，我们观察到 RPP 的强大抗氧化活性，这在减轻氧化应激和缓解高血压对主动脉、心脏和肾脏的损伤方面起着关键作用。此外，我们的研究还探讨了 RPP 对肠道微生物群的调节作用，提示其降压作用与调节肠道微生物群之间可能存在关联。我们之前的研究表明，RPP 可显著降低 SHR 大鼠的血压。这表明 RPP 可显著改善原发性高血压和 DOAC-盐诱导的继发性高血压，并可改善高血压引起的心脏和肾脏损伤。这些发现进一步支持 RPP 作为功能性抗高血压食品中活性成分的可能性。
