College of Life Sciences, Qingdao University, Qingdao 266071, China.
Qingdao Chenlan Pharmaceutical Co., Ltd., Qingdao 266105, China.
Molecules. 2023 Jul 28;28(15):5709. doi: 10.3390/molecules28155709.
Clam peptides, marine-derived biological peptides, have been broadly investigated and applied as health foods, among which immunomodulation is one of their biological activities that cannot be ignored in vivo. In this study, we concentrated on exploring the effects of peptides (RPPs) on immunomodulation and the balance of intestinal microbiota in hydrocortisone (HC)-induced immunosuppressed mice. The results revealed that RPPs could increase the thymus and spleen indices and number of white blood cells, promote the secretion level of cytokines (IL-2, IL-6, TNF-α, and INF-γ), repair the morphology of the spleen and thymus, and enhance the proliferation of T-lymphocyte subsets in immunosuppressed mice. Moreover, RPPs improved the abundance of beneficial bacteria and preserved the ecological equilibrium of the gut microbiota. In conclusion, RPPs have significant immunomodulatory effects on immunosuppressed mice and may be developed as immunomodulators or immune adjuvants in functional foods and drugs; they are also beneficial to the utilization of the high value of marine shellfish.
贝类肽是一种来源于海洋的生物活性肽，具有广泛的研究和应用价值，可作为保健品，其中免疫调节作用是其重要的生物活性之一。本研究以贝类活性肽（RPPs）为研究对象，探讨其对氢化可的松（HC）致免疫抑制小鼠的免疫调节和肠道微生态平衡的影响。结果表明，RPPs 能提高免疫抑制小鼠的胸腺、脾脏指数和白细胞数量，促进细胞因子（IL-2、IL-6、TNF-α、IFN-γ）的分泌水平，修复免疫抑制小鼠的脾脏和胸腺形态，增强 T 淋巴细胞亚群的增殖能力；同时，RPPs 能增加有益菌的丰度，维持肠道菌群生态平衡。综上所述，RPPs 对免疫抑制小鼠具有显著的免疫调节作用，有望开发为功能性食品和药物中的免疫调节剂或免疫佐剂，对提高贝类高值化利用具有重要意义。
