Shanghai Yuansi Standard Science and Technology Co., Ltd., Shanghai 200072, China.
Shanghai Key Laboratory of Crime Scene Evidence, Shanghai Research Institute of Criminal Science and Technology, Shanghai 200072, China.
Molecules. 2023 Nov 16;28(22):7625. doi: 10.3390/molecules28227625.
Carfentanil is an ultra-potent synthetic opioid. The Russian police force used both carfentanil and remifentanil to resolve a hostage incident in Moscow. This reported use sparked an interest in the pharmacology and toxicology of carfentanil in the human body, and data on its metabolites were later published. However, there have been few studies on the synthesis of carfentanil metabolites, and biological extraction has also put forward large uncertainty in subsequent studies. The aim of the present study is to investigate the synthesis of biphasic metabolites that are unique to carfentanil. The purpose was to produce corresponding metabolites conveniently, quickly, and at low cost that can be used for comparison with published structures and to confirm the administration of carfentanil.
卡芬太尼是一种超强效合成阿片类药物。俄罗斯警方曾使用卡芬太尼和瑞芬太尼来解决莫斯科的一起人质事件。这一报道引起了人们对卡芬太尼在人体中的药理学和毒理学的兴趣，随后发表了有关其代谢物的数据。然而，关于卡芬太尼代谢物的合成研究较少，生物提取在后续研究中也提出了很大的不确定性。本研究旨在探讨双峰代谢物的合成，这些代谢物是卡芬太尼所特有的。目的是方便、快速、低成本地生产相应的代谢物，可用于与已发表结构进行比较，并确认卡芬太尼的使用。
