表吡咯里西啶 A 和 B，两种新型吡咯里西啶生物碱来自海洋来源放线菌 sp. HU138。

Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China.

Key Laboratory of Horticultural Biotechnology of Taizhou, School of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou 318020, China.

Molecules. 2023 Nov 20;28(22):7672. doi: 10.3390/molecules28227672.

Two previously undescribed pyrrolizine alkaloids, named phenopyrrolizins A and B ( and ), were obtained from the fermentation broth of marine-derived sp. HU138. Their structures were established by extensive spectroscopic analysis, including 1D and 2D NMR spectra as well as HRESIMS data. The structure of was confirmed by single-crystal diffraction analysis and its racemization mechanism was proposed. The antifungal activity assay showed that could inhibit the mycelial growth of with the inhibitory rates of 18.9% and 35.9% at 20 μg/disc and 40 μg/disc, respectively.

从海洋来源的 sp. HU138 的发酵液中获得了两种以前未描述的吡咯里嗪生物碱，分别命名为 phenopyrrolizins A 和 B（和）。通过广泛的光谱分析，包括 1D 和 2D NMR 光谱以及 HRESIMS 数据，确定了它们的结构。通过单晶衍射分析确定了的结构，并提出了其外消旋化机制。抗真菌活性测定表明，在 20 μg/disc 和 40 μg/disc 时，能够抑制的菌丝生长，抑制率分别为 18.9%和 35.9%。