Nie Yi-Lei, Wu Yun-Dan, Wang Chuan-Xi, Lin Ru, Xie Yang, Fang Dong-Sheng, Jiang Hong, Lian Yun-Yang
a Fujian Provincial Key Laboratory of Screening for Novel Microbial Products , Fujian Institute of Microbiology , Fuzhou , China.
Nat Prod Res. 2018 Sep;32(18):2133-2138. doi: 10.1080/14786419.2017.1366479. Epub 2017 Aug 20.
Chemical investigation of a marine-derived actinomycete strain Micromonospora sp. FIM05328 isolated from a soil sample collected from the East China Sea, resulted in the discovery of a new 26-membered polyene macrolactam metabolite FW05328-1 (1), together with a known polyene with pyridone ring compound aurodox (2). The structures of compounds 1 and 2 were determined by the detailed analysis of 1D, 2D NMR and HR-TOF-MS data, along with literature data analysis. 1 and 2 exhibited excellent antiproliferative activities against KYSE30, KYSE180 and EC109 human tumour cell lines, but displayed no antibacterial activities against bacteria or fungi were tested.
对从中国东海采集的土壤样本中分离得到的海洋来源放线菌菌株小单孢菌属Micromonospora sp. FIM05328进行化学研究，发现了一种新的26元多烯大环内酰胺代谢产物FW05328-1（1），以及一种已知的含吡啶酮环的多烯化合物奥多霉素（2）。通过对一维、二维核磁共振和高分辨飞行时间质谱数据的详细分析以及文献数据分析，确定了化合物1和2的结构。化合物1和2对KYSE30、KYSE180和EC109人肿瘤细胞系表现出优异的抗增殖活性，但对所测试的细菌或真菌均无抗菌活性。
