四氢卡奇霉素 Q，一种新型含独特糖基的螺环四烯类抗生素，来源于海洋来源放线菌小单孢菌 LS276。
Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China.
出版信息
Mar Drugs. 2018 Feb 24;16(2):74. doi: 10.3390/md16020074.
A new spirotetronate glycoside tetrocarcin Q () and six known analogues tetrocarcin A (), AC6H (), tetrocarcin N (), tetrocarcin H (), arisostatin A (), and tetrocarcin F1 () were isolated from the fermentation broth of the marine-derived actinomycete LS276. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopy, as well as HR-ESI-MS analysis. The absolute configurations of their stereogenic carbons were determined by circular dichroism (CD) analysis. Compound possesses 2-deoxy-allose, which is a unique sugar type at the C-9 position. This type has not been found in the previously reported spirotetronate glycosides. Compound displayed moderate antibacterial activity against ATCC 63501 with minimum inhibitory concentration (MIC) value of 12.5 μM.
从海洋来源放线菌 LS276 的发酵液中分离得到了一种新的螺缩酮糖苷四卡素 Q（）和六种已知类似物四卡素 A（）、AC6H（）、四卡素 N（）、四卡素 H（）、arisostatin A（）和四卡素 F1（）。基于 1D 和 2D-NMR 光谱以及 HR-ESI-MS 分析确定了它们的化学结构。通过圆二色性（CD）分析确定了它们手性碳原子的绝对构型。化合物具有 2-脱氧-allose，这是 C-9 位置的独特糖型。这种类型以前在报道的螺缩酮糖苷中没有发现。化合物对 ATCC 63501 表现出中等的抗菌活性，最小抑菌浓度（MIC）值为 12.5 μM。
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