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γ-钴60射线辐照制备的壳聚糖与氨基葡萄糖美拉德反应产物的抗菌活性及细胞毒性

Antibacterial Activity against and Cytotoxicity of Maillard Reaction Product of Chitosan and Glucosamine Prepared by Gamma Co-60 Ray Irradiation.

作者信息

Le Anh Quoc, Dang Van Phu, Nguyen Ngoc Duy, Nguyen Chi Thuan, Nguyen Quoc Hien

机构信息

Faculty of Biology-Biotechnology, University of Science, Ho Chi Minh City 700000, Vietnam.

Vietnam National University, Ho Chi Minh City 700000, Vietnam.

出版信息

Polymers (Basel). 2023 Nov 13;15(22):4397. doi: 10.3390/polym15224397.

DOI:10.3390/polym15224397
PMID:38006121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10675730/
Abstract

In this study, the gamma ray-induced Maillard reaction method was carried out for chitosan (CTS) and glucosamine (GA) to improve the water solubility and antibacterial activity. The mixture solution of CTS and GA was exposed to gamma rays at a dose of 25 kGy and freeze-dried to obtain a Maillard reaction product (MRP) powder. The physicochemical and biological properties of the CTS-GA MRP powder were investigated. The CTS-GA MRP powder expressed good solubility at a concentration of 0.05 g/mL. In addition, the result of the antibacterial activity test against revealed that the CTS-GA MRP powder exhibited highly antibacterial activity at pH 7; in particular, bacterial density was reduced by over 4 logs. Furthermore, the cytotoxicity test of the CTS-GA MRP powder on mouse fibroblast cells (L929) showed non-cytotoxicity with high cell viability (>90%) at concentrations of 0.1-1 mg/mL. Owing to the high antibacterial activity and low cytotoxicity, the water-soluble CTS-GA MRP powder can be used as a favorable natural preservative for food and cosmetics.

摘要

在本研究中，采用γ射线诱导的美拉德反应方法对壳聚糖（CTS）和氨基葡萄糖（GA）进行处理，以提高其水溶性和抗菌活性。将CTS和GA的混合溶液以25 kGy的剂量暴露于γ射线下，然后冷冻干燥，得到美拉德反应产物（MRP）粉末。对CTS-GA MRP粉末的理化性质和生物学特性进行了研究。CTS-GA MRP粉末在浓度为0.05 g/mL时表现出良好的溶解性。此外，针对[此处原文缺失具体受试对象]的抗菌活性测试结果表明，CTS-GA MRP粉末在pH 7时表现出高度抗菌活性；特别是，细菌密度降低了超过4个对数级。此外，CTS-GA MRP粉末对小鼠成纤维细胞（L929）的细胞毒性测试表明，在浓度为0.1 - 1 mg/mL时具有非细胞毒性，细胞活力较高（>90%）。由于具有高抗菌活性和低细胞毒性，水溶性CTS-GA MRP粉末可作为食品和化妆品的优良天然防腐剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/bf46a36c78a1/polymers-15-04397-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/59568969cecf/polymers-15-04397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/b59ecbf66298/polymers-15-04397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/ccd518165989/polymers-15-04397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/294180ddad60/polymers-15-04397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/0498c951b97a/polymers-15-04397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/bf46a36c78a1/polymers-15-04397-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/59568969cecf/polymers-15-04397-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/b59ecbf66298/polymers-15-04397-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/ccd518165989/polymers-15-04397-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/294180ddad60/polymers-15-04397-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/0498c951b97a/polymers-15-04397-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c201/10675730/bf46a36c78a1/polymers-15-04397-g008.jpg

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Food Chem. 2021 Jul 1;349:129072. doi: 10.1016/j.foodchem.2021.129072. Epub 2021 Jan 12.
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Anti-Oxidant and Anti-Diabetes Potential of Water-Soluble Chitosan-Glucose Derivatives Produced by Maillard Reaction.
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Polymers (Basel). 2019 Oct 18;11(10):1714. doi: 10.3390/polym11101714.
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Carbohydr Polym. 2019 Nov 15;224:115158. doi: 10.1016/j.carbpol.2019.115158. Epub 2019 Aug 8.
5
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6
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