Ageev A K, Sidorin V S, Rogachev M V, Timofeev I V
Arkh Patol. 1986;48(10):33-9.
Morphological studies of the thymus and the spleen were made in 54 alcohol addicts and 53 cases of other death cause at the age from 25 to 65 yr. Alcoholism was found to induce the reduction in thymus size and the number of its lobes with a simultaneous decrease of lymphocyte content in them; in the lymphatic follicles of the spleen (in the presence of infectious processes) absence of bright multiplication centres and alkaline phosphatase activity in their mantle zone cells was noted. There appeared to be a statistically significant difference in the amount of the parenchyma in the thymus of alcoholics (p less than 0.017) compared to that of the control group 0.68 +/- 0.09 g and 1.33 +/- 0.21 g, respectively and this figure was almost 4-fold less, than the average age norms, 0.26 +/- 0.03 g; the quantitative content of the splenic pulp in alcoholics also had a statistically significant difference compared to the control group (P less than 0.001), 6.37 +/- 0.66 g vs. 12.59 +/- 0.98 g, respectively. The data obtained indicate the development of immunodeficiency states in alcoholism and basing on the changes occurring in the thymus and spleen they can be referred to a combined T- and B-cell form of immunodeficiency.
对54名年龄在25至65岁的酗酒者以及53名其他死因的病例进行了胸腺和脾脏的形态学研究。发现酗酒会导致胸腺体积减小及其叶数减少，同时胸腺内淋巴细胞含量降低；在脾脏的淋巴滤泡中（存在感染过程时），观察到明显的增殖中心缺失，其套区细胞中碱性磷酸酶活性也缺失。与对照组相比，酗酒者胸腺实质的量存在统计学显著差异（p小于0.017），分别为0.68±0.09克和1.33±0.21克，且该数值比平均年龄标准值0.26±0.03克几乎少4倍；酗酒者脾髓的定量含量与对照组相比也存在统计学显著差异（P小于0.001），分别为6.37±0.66克和12.59±0.98克。所获得的数据表明酗酒会导致免疫缺陷状态的发展，基于胸腺和脾脏发生的变化，可将其归为T细胞和B细胞联合形式的免疫缺陷。
