Department of Immunology, Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Zunyi Medical University, Guizhou, China.
Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gene. 2024 Feb 5;894:148023. doi: 10.1016/j.gene.2023.148023. Epub 2023 Nov 23.
To investigate the association of melatonin receptor 1B (MTNR1B) gene variations and pre-pregnancy body mass index (BMI) with gestational diabetes mellitus (GDM).
In this study, 1566 Chinese Han pregnant women were enrolled and multiple genetic models were used to evaluate the association between MTNR1B gene polymorphisms and the risk of GDM. The clinical value of pre-pregnancy BMI in predicting GDM was analyzed and evaluated using receiver operating characteristic (ROC) curves. Several methods of analysis were used to examine the impact of gene-gene and gene-BMI interactions on the incidence of GDM influence.
For the MTNR1B gene, rs1387153 (C > T), rs10830962 (C > G), rs4753426 (T > C), and rs10830963 (C > G) are all risk mutations associated with the susceptibility of GDM. The ROC curve analysis indicated that the BMI demonstrated an area under the curve (AUC) of 0.595. Alongside, the sensitivity and specificity stood at 0.676 and 0.474 respectively. The maximum Joden index was found to be 0.150, with a corresponding critical BMI value of 20.5691 kg/m. Interaction analysis revealed that gene-gene and gene-BMI interactions had no significant effect on GDM occurrence.
MTNR1B genetic variations confers the risk to GDM in Chinese women. Furthermore, the high pre-pregnancy BMI (≥20.5691 kg/m) significantly increases the risk of GDM in Chinese women.
研究褪黑素受体 1B（MTNR1B）基因变异与孕前体重指数（BMI）与妊娠期糖尿病（GDM）的关系。
本研究纳入了 1566 名中国汉族孕妇，采用多种遗传模型评估 MTNR1B 基因多态性与 GDM 风险的关系。分析并评估了孕前 BMI 预测 GDM 的临床价值，采用受试者工作特征（ROC）曲线。采用几种分析方法研究了基因-基因和基因-BMI 相互作用对 GDM 发生率的影响。
对于 MTNR1B 基因，rs1387153（C>T）、rs10830962（C>G）、rs4753426（T>C）和 rs10830963（C>G）均为与 GDM 易感性相关的风险突变。ROC 曲线分析表明，BMI 的曲线下面积（AUC）为 0.595。同时，敏感性和特异性分别为 0.676 和 0.474。最大 Joden 指数为 0.150，对应的临界 BMI 值为 20.5691 kg/m²。交互分析表明，基因-基因和基因-BMI 相互作用对 GDM 的发生没有显著影响。
MTNR1B 基因变异使中国女性患 GDM 的风险增加。此外，高孕前 BMI（≥20.5691 kg/m²）显著增加了中国女性患 GDM 的风险。
