Weinstein I, Cook G A, Heimberg M
Biochem J. 1986 Jul 15;237(2):593-6. doi: 10.1042/bj2370593.
Treatment of female rats with ethynyloestradiol decreased both the activity of carnitine palmitoyltransferase and its Ki value for malonyl-CoA compared with pair-fed control rats. In starved rats, carnitine palmitoyltransferase activity and its Ki value for malonyl-CoA were both elevated as expected. Oestrogen treatment had no effect on carnitine palmitoyltransferase activity in the starved state, but the Ki value for malonyl-CoA was substantially decreased by oestrogen. Treatment with a more physiological concentration of ethynyloestradiol (15 micrograms/kg body wt. per day) also produced a decrease in the Ki value for malonyl-CoA. These data suggest that the oestrogen may produce its anti-ketogenic effect by increasing the affinity of carnitine palmitoyltransferase for its physiological inhibitor, malonyl-CoA.
与成对喂养的对照大鼠相比，用乙炔雌二醇处理雌性大鼠可降低肉碱棕榈酰转移酶的活性及其对丙二酰辅酶A的Ki值。在饥饿的大鼠中，肉碱棕榈酰转移酶活性及其对丙二酰辅酶A的Ki值均如预期升高。雌激素处理对饥饿状态下的肉碱棕榈酰转移酶活性没有影响，但雌激素使丙二酰辅酶A的Ki值大幅降低。用更生理浓度的乙炔雌二醇（每天15微克/千克体重）处理也会使丙二酰辅酶A的Ki值降低。这些数据表明，雌激素可能通过增加肉碱棕榈酰转移酶对其生理抑制剂丙二酰辅酶A的亲和力来产生其抗生酮作用。
