雌激素对肝脏线粒体中肉碱棕榈酰转移酶的调节作用。
Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria.
作者信息
Weinstein I, Cook G A, Heimberg M
出版信息
Biochem J. 1986 Jul 15;237(2):593-6. doi: 10.1042/bj2370593.
Abstract
Treatment of female rats with ethynyloestradiol decreased both the activity of carnitine palmitoyltransferase and its Ki value for malonyl-CoA compared with pair-fed control rats. In starved rats, carnitine palmitoyltransferase activity and its Ki value for malonyl-CoA were both elevated as expected. Oestrogen treatment had no effect on carnitine palmitoyltransferase activity in the starved state, but the Ki value for malonyl-CoA was substantially decreased by oestrogen. Treatment with a more physiological concentration of ethynyloestradiol (15 micrograms/kg body wt. per day) also produced a decrease in the Ki value for malonyl-CoA. These data suggest that the oestrogen may produce its anti-ketogenic effect by increasing the affinity of carnitine palmitoyltransferase for its physiological inhibitor, malonyl-CoA.
摘要
与成对喂养的对照大鼠相比，用乙炔雌二醇处理雌性大鼠可降低肉碱棕榈酰转移酶的活性及其对丙二酰辅酶A的Ki值。在饥饿的大鼠中，肉碱棕榈酰转移酶活性及其对丙二酰辅酶A的Ki值均如预期升高。雌激素处理对饥饿状态下的肉碱棕榈酰转移酶活性没有影响，但雌激素使丙二酰辅酶A的Ki值大幅降低。用更生理浓度的乙炔雌二醇（每天15微克/千克体重）处理也会使丙二酰辅酶A的Ki值降低。这些数据表明，雌激素可能通过增加肉碱棕榈酰转移酶对其生理抑制剂丙二酰辅酶A的亲和力来产生其抗生酮作用。
相似文献
1
Regulation by oestrogen of carnitine palmitoyltransferase in hepatic mitochondria.雌激素对肝脏线粒体中肉碱棕榈酰转移酶的调节作用。
Biochem J. 1986 Jul 15;237(2):593-6. doi: 10.1042/bj2370593.
2
Interacting effects of L-carnitine and malonyl-CoA on rat liver carnitine palmitoyltransferase.左旋肉碱与丙二酰辅酶A对大鼠肝脏肉碱棕榈酰转移酶的相互作用
Biochem J. 1985 Aug 15;230(1):161-7. doi: 10.1042/bj2300161.
3
Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.肉碱棕榈酰转移酶的滞后行为。丙二酰辅酶A预温育的影响。
Biochem J. 1986 Jun 15;236(3):917-9. doi: 10.1042/bj2360917.
4
Effects of thyroidectomy and starvation on the activity and properties of hepatic carnitine palmitoyltransferase.甲状腺切除术和饥饿对肝脏肉碱棕榈酰转移酶活性及特性的影响。
Biochem J. 1982 Dec 15;208(3):667-72. doi: 10.1042/bj2080667.
5
Hepatic mitochondrial inner membrane properties and carnitine palmitoyltransferase A and B. Effect of diabetes and starvation.肝线粒体内膜特性以及肉碱棕榈酰转移酶A和B。糖尿病和饥饿的影响。
Biochem J. 1985 Dec 1;232(2):445-50. doi: 10.1042/bj2320445.
6
The effect of malonyl-CoA on overt and latent carnitine acyltransferase activities in rat liver and adipocyte mitochondria.丙二酰辅酶A对大鼠肝脏和脂肪细胞线粒体中显性和潜在肉碱酰基转移酶活性的影响。
Biochem J. 1983 Feb 15;210(2):591-7. doi: 10.1042/bj2100591.
7
The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.禁食对肝脏肉碱棕榈酰转移酶活性的影响及其被丙二酰辅酶A的抑制作用。
Biochim Biophys Acta. 1981 Sep 24;665(3):628-31. doi: 10.1016/0005-2760(81)90282-4.
8
Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values.肉碱棕榈酰转移酶对丙二酸单酰辅酶A抑制的敏感性差异是由于Ki值的不同。
J Biol Chem. 1984 Oct 10;259(19):12030-3.
9
Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase.给大鼠喂食洛伐他汀会增加肝脏线粒体外肉碱棕榈酰转移酶的活性。
Biochem Biophys Res Commun. 1988 Feb 15;150(3):1077-82. doi: 10.1016/0006-291x(88)90739-5.
10
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.pH对丙二酰辅酶A抑制肉碱棕榈酰转移酶I的影响。
Biochem J. 1983 May 15;212(2):521-4. doi: 10.1042/bj2120521.
引用本文的文献
1
Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension.性别在肺动脉高压氧化还原稳态调节中的作用
Antioxidants (Basel). 2019 May 16;8(5):135. doi: 10.3390/antiox8050135.
2
The dietary protein/carbohydrate ratio differentially modifies lipogenesis and protein synthesis in the mammary gland, liver and adipose tissue during gestation and lactation.在妊娠和哺乳期，饮食中的蛋白质/碳水化合物比例会差异地调节乳腺、肝脏和脂肪组织中的脂肪生成和蛋白质合成。
PLoS One. 2013 Jul 16;8(7):e69338. doi: 10.1371/journal.pone.0069338. Print 2013.
3
Establishing a relationship between prolactin and altered fatty acid β-oxidation via carnitine palmitoyl transferase 1 in breast cancer cells.建立催乳素与乳腺癌细胞中肉毒碱棕榈酰转移酶 1 改变的脂肪酸β氧化之间的关系。
BMC Cancer. 2011 Feb 4;11:56. doi: 10.1186/1471-2407-11-56.
4
cDNA cloning, sequence analysis, and chromosomal localization of the gene for human carnitine palmitoyltransferase.人肉碱棕榈酰转移酶基因的cDNA克隆、序列分析及染色体定位
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):661-5. doi: 10.1073/pnas.88.2.661.
5
A study of properties and abundance of the components of liver carnitine palmitoyltransferases in mitochondrial inner and outer membranes. Effects of hypothyroidism, fasting and a ketotic diabetic state.线粒体内膜和外膜中肝脏肉碱棕榈酰转移酶成分的性质和丰度研究。甲状腺功能减退、禁食和酮症糖尿病状态的影响。
Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):611-7. doi: 10.1042/bj2770611.
本文引用的文献
1
Studies in fat metabolism. I. The colorimetric determination of ketone bodies in biological fluids.脂肪代谢研究。I. 生物体液中酮体的比色测定。
J Clin Invest. 1951 Dec;30(12:2):1483-5. doi: 10.1172/JCI102557.
2
The determination of enzyme inhibitor constants.酶抑制剂常数的测定
Biochem J. 1953 Aug;55(1):170-1. doi: 10.1042/bj0550170.
3
Increased formation of triglyceride from oleate in perfused livers from pregnant rats.在怀孕大鼠的灌注肝脏中，油酸生成甘油三酯的过程增强。
Endocrinology. 1980 Aug;107(2):584-90. doi: 10.1210/endo-107-2-584.
4
The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.禁食对肝脏肉碱棕榈酰转移酶活性的影响及其被丙二酰辅酶A的抑制作用。
Biochim Biophys Acta. 1981 Sep 24;665(3):628-31. doi: 10.1016/0005-2760(81)90282-4.
5
6
Effects of fasting, adrenalectomy and streptozotocin-diabetes on sensitivity of hepatic carnitine acyltransferase to malonyl CoA.禁食、肾上腺切除及链脲佐菌素诱导的糖尿病对肝脏肉碱酰基转移酶对丙二酰辅酶A敏感性的影响。
FEBS Lett. 1981 Jul 6;129(2):225-8. doi: 10.1016/0014-5793(81)80170-6.
7
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.pH对丙二酰辅酶A抑制肉碱棕榈酰转移酶I的影响。
Biochem J. 1983 May 15;212(2):521-4. doi: 10.1042/bj2120521.
8
Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values.肉碱棕榈酰转移酶对丙二酸单酰辅酶A抑制的敏感性差异是由于Ki值的不同。
J Biol Chem. 1984 Oct 10;259(19):12030-3.
9
Lipoprotein lipid transport by livers from normal and CCl-4-poisoned animals.来自正常动物和四氯化碳中毒动物肝脏的脂蛋白脂质转运
Am J Physiol. 1965 Nov;209(5):1053-60. doi: 10.1152/ajplegacy.1965.209.5.1053.
10
Sexual influences on hepatic secretion of triglyceride.性对肝脏甘油三酯分泌的影响。
Biochim Biophys Acta. 1972 Sep 7;280(1):82-5. doi: 10.1016/0005-2760(72)90214-7.
Zotero 插件