Anthelmintic potential of sulphonamides and seeds extract on experimentally infected mice.

Since 1980s, no new drugs were described for treatment of heterophyiasis with many side effects of the currently used drug; praziquantel. This work aimed to study the therapeutic effect of clorsulon (sulphoamide) and aqueous extract of in the treatment of experimental heterophyiasis. Mice were infected with encysted metacercaiae of obtained from infected fish flesh. Mice were divided into five groups according to the drug used. The treatment started two weeks post-infection. Our results showed reduction of the recovered worm count with high efficacy of clorsulon and a moderate effect of which was increased in the second week with much improvement of the intestinal histopathological changes. Scanning electron microscopy of adult obtained from the intestine of mice treated with praziquantel appeared contracted with multiple small vesicles over the dorsal surface. Clorsulon produced loss of the spines on the lateral sides of the parasite with few vesicles whereas seeds showed complete loss of the spines. In conclusion, clorsulon has high efficacy against infection. Although the extract of showed moderate curative effect against this parasite, it can be used in combination with other agents for a better synergistic effect.