Ashour Dalia S, Deyab Fetouh A, Eliwa Kamal F, El-Kowrany Samy I
Medical Parasitology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
J Parasit Dis. 2023 Dec;47(4):697-706. doi: 10.1007/s12639-023-01620-8. Epub 2023 Jul 26.
Since 1980s, no new drugs were described for treatment of heterophyiasis with many side effects of the currently used drug; praziquantel. This work aimed to study the therapeutic effect of clorsulon (sulphoamide) and aqueous extract of in the treatment of experimental heterophyiasis. Mice were infected with encysted metacercaiae of obtained from infected fish flesh. Mice were divided into five groups according to the drug used. The treatment started two weeks post-infection. Our results showed reduction of the recovered worm count with high efficacy of clorsulon and a moderate effect of which was increased in the second week with much improvement of the intestinal histopathological changes. Scanning electron microscopy of adult obtained from the intestine of mice treated with praziquantel appeared contracted with multiple small vesicles over the dorsal surface. Clorsulon produced loss of the spines on the lateral sides of the parasite with few vesicles whereas seeds showed complete loss of the spines. In conclusion, clorsulon has high efficacy against infection. Although the extract of showed moderate curative effect against this parasite, it can be used in combination with other agents for a better synergistic effect.
自20世纪80年代以来，针对异形吸虫病的治疗没有新的药物出现，而目前使用的药物吡喹酮有许多副作用。这项工作旨在研究氯舒隆（磺胺）和[未提及的植物名称]水提取物对实验性异形吸虫病的治疗效果。小鼠感染从感染鱼肉中获得的[未提及的异形吸虫名称]包囊后尾蚴。根据使用的药物将小鼠分为五组。感染后两周开始治疗。我们的结果显示，氯舒隆的驱虫效果显著，可减少回收的虫数，[未提及的植物名称]水提取物有中等效果，在第二周效果增强，肠道组织病理学变化有很大改善。用吡喹酮治疗的小鼠肠道中获得的成虫扫描电子显微镜观察显示，成虫收缩，背面有多个小泡。氯舒隆使寄生虫侧面的棘突消失，有少量小泡，而[未提及的植物名称]种子显示棘突完全消失。总之，氯舒隆对[未提及的异形吸虫名称]感染有高效。虽然[未提及的植物名称]提取物对这种寄生虫显示出中等疗效，但它可与其他药物联合使用以获得更好的协同效果。
