大鼠妊娠晚期母体和胎儿组织中葡萄糖可用性及胰岛素分泌对体内脂肪生成的调节。葡萄糖插管、链脲佐菌素诱导的糖尿病及饥饿的影响。
Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and foetal tissues during late gestation in the rat. Effect of glucose intubation, streptozotocin-induced diabetes and starvation.
作者信息
Lorenzo M, Benito M, Caldés T, Medina J M
出版信息
Biochem J. 1983 Dec 15;216(3):695-9. doi: 10.1042/bj2160695.
Abstract
Administration of an oral load of glucose did not change the rate of lipogenesis in maternal liver during late gestation. However, streptozotocin-induced diabetes or starvation decreased maternal liver lipogenesis at 20-22 days of gestation. Glucose intubation, on the other hand, increased foetal lipogenesis at 21-22 days. In addition, maternal starvation decreased foetal lipogenesis and plasma insulin concentration. However, chronic hyperglycaemia induced by streptozotocin administration to the mother did not change foetal liver lipogenesis.
摘要
口服葡萄糖负荷并未改变妊娠晚期母体肝脏的脂肪生成速率。然而，链脲佐菌素诱导的糖尿病或饥饿会降低妊娠20 - 22天时母体肝脏的脂肪生成。另一方面，葡萄糖插管会增加妊娠21 - 22天时胎儿的脂肪生成。此外，母体饥饿会降低胎儿的脂肪生成和血浆胰岛素浓度。然而，给母体注射链脲佐菌素诱导的慢性高血糖症并未改变胎儿肝脏的脂肪生成。
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Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and foetal tissues during late gestation in the rat. Effect of glucose intubation, streptozotocin-induced diabetes and starvation.大鼠妊娠晚期母体和胎儿组织中葡萄糖可用性及胰岛素分泌对体内脂肪生成的调节。葡萄糖插管、链脲佐菌素诱导的糖尿病及饥饿的影响。
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Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat.大鼠妊娠晚期母体和胎儿组织中的体内脂肪生成。
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Effect of gestational alloxan diabetes and fasting on fetal lipogenesis and lipid deposition in pigs.妊娠性四氧嘧啶糖尿病和禁食对猪胎儿脂肪生成及脂质沉积的影响。
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Relationship between lipogenesis and glycogen synthesis in maternal and foetal tissues during late gestation in the rat. Effect of dexamethasone.大鼠妊娠晚期母胎组织中脂肪生成与糖原合成的关系。地塞米松的作用。
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The acute effects of streptozotocin-induced diabetes on rat liver glycerolipid biosynthesis.链脲佐菌素诱导的糖尿病对大鼠肝脏甘油脂质生物合成的急性影响。
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