大鼠妊娠晚期母体和胎儿组织中葡萄糖可用性及胰岛素分泌对体内脂肪生成的调节。葡萄糖插管、链脲佐菌素诱导的糖尿病及饥饿的影响。
Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and foetal tissues during late gestation in the rat. Effect of glucose intubation, streptozotocin-induced diabetes and starvation.
作者信息
Lorenzo M, Benito M, Caldés T, Medina J M
出版信息
Biochem J. 1983 Dec 15;216(3):695-9. doi: 10.1042/bj2160695.
Abstract
Administration of an oral load of glucose did not change the rate of lipogenesis in maternal liver during late gestation. However, streptozotocin-induced diabetes or starvation decreased maternal liver lipogenesis at 20-22 days of gestation. Glucose intubation, on the other hand, increased foetal lipogenesis at 21-22 days. In addition, maternal starvation decreased foetal lipogenesis and plasma insulin concentration. However, chronic hyperglycaemia induced by streptozotocin administration to the mother did not change foetal liver lipogenesis.
摘要
口服葡萄糖负荷并未改变妊娠晚期母体肝脏的脂肪生成速率。然而，链脲佐菌素诱导的糖尿病或饥饿会降低妊娠20 - 22天时母体肝脏的脂肪生成。另一方面，葡萄糖插管会增加妊娠21 - 22天时胎儿的脂肪生成。此外，母体饥饿会降低胎儿的脂肪生成和血浆胰岛素浓度。然而，给母体注射链脲佐菌素诱导的慢性高血糖症并未改变胎儿肝脏的脂肪生成。
相似文献
1
Regulation of lipogenesis in vivo by glucose availability and insulin secretion in maternal and foetal tissues during late gestation in the rat. Effect of glucose intubation, streptozotocin-induced diabetes and starvation.
Biochem J. 1983 Dec 15;216(3):695-9. doi: 10.1042/bj2160695.
2
Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat.
Biochem J. 1981 Aug 15;198(2):425-8. doi: 10.1042/bj1980425.
3
Placental enzymes of glycolysis, gluconeogenesis and lipogenesis in the diabetic rat and in starvation. Comparison with maternal and foetal liver.
Diabetologia. 1978 Dec;15(6):481-5. doi: 10.1007/BF02342874.
4
Interactions between insulin and thyroid hormone in the control of lipogenesis.
Biochem J. 1983 Mar 15;210(3):937-44. doi: 10.1042/bj2100937.
5
Regulation of hepatic lipogenesis in starved and diabetic animals by thyroid hormone.
Biosci Rep. 1981 Oct;1(10):757-64. doi: 10.1007/BF01114797.
6
Relationship between lipogenesis and glycogen synthesis in maternal and foetal tissues during late gestation in the rat. Effect of dexamethasone.
Biochem J. 1982 Jun 15;204(3):865-8. doi: 10.1042/bj2040865.
7
The regulation of lipogenesis in vivo in the lactating mammary gland of the rat during the starved-refed transition. Studies wtih acarbose, a glucosidase inhibitor.
Biochem J. 1987 Feb 15;242(1):235-43. doi: 10.1042/bj2420235.
8
Regulation of lactating-rat mammary-gland lipogenesis by insulin and glucagon in vivo. The role and site of action of insulin in the transition to the starved state.
Biochem J. 1984 Oct 15;223(2):345-51. doi: 10.1042/bj2230345.
9
Regulation of lipogenesis and of non-saponifiable-lipid synthesis in vivo at birth and after prolonged starvation in the newborn rat.
Biochem J. 1984 Dec 15;224(3):823-8. doi: 10.1042/bj2240823.
10
Effects of glucose-containing peritoneal-dialysis solutions on rates of lipogenesis in vivo in the liver, brown and white adipose tissue of chronic uraemic rats.
Biochem J. 1983 Aug 15;214(2):459-64. doi: 10.1042/bj2140459.
引用本文的文献
1
Regulation of lipogenesis and of non-saponifiable-lipid synthesis in vivo at birth and after prolonged starvation in the newborn rat.
Biochem J. 1984 Dec 15;224(3):823-8. doi: 10.1042/bj2240823.
2
The role of prolactin and progesterone in the regulation of lipogenesis in maternal and foetal rat liver in vivo and in isolated hepatocytes during the last day of gestation.
Biochem J. 1986 Oct 1;239(1):135-9. doi: 10.1042/bj2390135.
3
Role of reversible phosphorylation in mediating changes in the activity of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase during pregnancy and lactation in the rat.
Biochem J. 1987 Dec 15;248(3):993-6. doi: 10.1042/bj2480993.
4
Regulation of rat foetal lipogenesis in brown adipose tissue in vivo and in isolated brown adipocytes during the last day of, and after prolonged, gestation.
Biochem J. 1987 Apr 15;243(2):617-20. doi: 10.1042/bj2430617.
本文引用的文献
1
HYPERLIPEMIA AND KETOSIS IN THE PREGNANT RAT.
Am J Physiol. 1964 Apr;206:796-804. doi: 10.1152/ajplegacy.1964.206.4.796.
2
Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.
Biochem J. 1963 Jan;86(1):22-7. doi: 10.1042/bj0860022.
3
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
4
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus.
Lancet. 1963 Apr 13;1(7285):785-9. doi: 10.1016/s0140-6736(63)91500-9.
5
An abnormality of nonesterified fatty acid metabolism in diabetes mellitus.
Diabetes. 1957 Nov-Dec;6(6):475-9. doi: 10.2337/diab.6.6.475.
6
Lipogenesis in vivo in maternal and foetal tissues during late gestation in the rat.
Biochem J. 1981 Aug 15;198(2):425-8. doi: 10.1042/bj1980425.
7
Effect of gestational alloxan diabetes and fasting on fetal lipogenesis and lipid deposition in pigs.
Biol Neonate. 1981;40(3-4):105-12. doi: 10.1159/000241478.
8
Relationship between lipogenesis and glycogen synthesis in maternal and foetal tissues during late gestation in the rat. Effect of dexamethasone.
Biochem J. 1982 Jun 15;204(3):865-8. doi: 10.1042/bj2040865.
9
The acute effects of streptozotocin-induced diabetes on rat liver glycerolipid biosynthesis.
Biochim Biophys Acta. 1981 Dec 23;666(3):482-92. doi: 10.1016/0005-2760(81)90310-6.
10
Effects of insulin and maternal diabetes on fetal lipogenesis in the rat.
Enzyme. 1983;29(2):126-30. doi: 10.1159/000469617.
Zotero 插件