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小鼠对N-τ-甲基组氨酸的性别和表型依赖性代谢

Sex- and phenotype-dependent metabolism of N tau-methylhistidine by mice.

作者信息

Harris C I, Rucklidge G J, McDiarmid R M, Milne G

出版信息

Biochem J. 1986 Oct 1;239(1):229-32. doi: 10.1042/bj2390229.

DOI:10.1042/bj2390229
PMID:3800982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1147265/
Abstract

The metabolism of N tau-[Me-14C]methylhistidine by mice was influenced by both the sex and the phenotype of the animal. After subcutaneous injection of labelled N tau-methylhistidine, recoveries of radioactivity in excreta were incomplete, and the distributions of radioactivity showed that different mouse phenotypes degraded N tau-methylhistidine in vivo to different extents. Hence the excretion of N tau-methylhistidine by mice cannot be used as an index of protein breakdown in vivo.

摘要

小鼠对Nτ-[甲基-¹⁴C]甲基组氨酸的代谢受动物的性别和表型影响。皮下注射标记的Nτ-甲基组氨酸后，排泄物中的放射性回收率不完全，且放射性分布表明不同小鼠表型在体内对Nτ-甲基组氨酸的降解程度不同。因此，小鼠排泄Nτ-甲基组氨酸不能用作体内蛋白质分解的指标。

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Sex- and phenotype-dependent metabolism of N tau-methylhistidine by mice.小鼠对N-τ-甲基组氨酸的性别和表型依赖性代谢
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2
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Br J Nutr. 1987 May;57(3):467-78. doi: 10.1079/bjn19870054.
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High-performance liquid chromatographic method for the analysis of N tau-methylhistidine in food, chicken excreta, and rat urine.用于分析食品、鸡排泄物和大鼠尿液中N-τ-甲基组氨酸的高效液相色谱法。
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Quantitative importance of non-skeletal-muscle N tau-methylhistidine and creatine in human urine.人尿中非骨骼肌Nτ-甲基组氨酸和肌酸的定量重要性。
Biochem J. 1981 Nov 15;200(2):449-52. doi: 10.1042/bj2000449.

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本文引用的文献

1
The occurrence of the N tau-methylhistidine-containing dipeptide, balenine, in muscle extracts of various mammals.
Biochem Soc Trans. 1980 Oct;8(5):552. doi: 10.1042/bst0080552.
2
A new metabolism cage suitable for the study of mice.一种适用于小鼠研究的新型代谢笼。
Lab Anim. 1980 Jul;14(3):213-6. doi: 10.1258/002367780780937517.
3
The urinary excretion of N tau-methyl histidine in sheep: an invalid index of muscle protein breakdown.绵羊中N-τ-甲基组氨酸的尿排泄：肌肉蛋白质分解的无效指标。
Br J Nutr. 1980 Sep;44(2):129-40. doi: 10.1079/bjn19800020.
4
The inadequacy of urinary N tau-methyl histidine excretion in the pig as a measure of muscle protein breakdown.
Br J Nutr. 1981 Mar;45(2):423-9. doi: 10.1079/bjn19810117.
5
The urinary excretion of N tau-methyl histidine by cattle: validation as an index of muscle protein breakdown.牛的N-τ-甲基组氨酸尿排泄量：作为肌肉蛋白质分解指标的验证
Br J Nutr. 1981 Mar;45(2):411-22. doi: 10.1079/bjn19810116.
6
Metabolism of administered 3-methylhistidine. Lack of muscle transfer ribonucleic acid charging and quantitative excretion as 3-methylhistidine and its N-acetyl derivative.所给予的3-甲基组氨酸的代谢。缺乏肌肉转移核糖核酸的负载以及3-甲基组氨酸及其N-乙酰衍生物的定量排泄。
J Biol Chem. 1972 Jun 10;247(11):3592-600.
7
Growth of adipose and lean tissue mass in hindlimbs of genetically obese mice during preobese and obese phases of development.在基因肥胖小鼠发育的肥胖前期和肥胖期，其后肢脂肪组织和瘦组织质量的增长情况。
Am J Clin Nutr. 1975 Feb;28(2):157-61. doi: 10.1093/ajcn/28.2.157.
8
Skeletal muscle accretion and turnover in lean and obese (ob/ob) mice.瘦小鼠和肥胖（ob/ob）小鼠的骨骼肌增生与更新
Metabolism. 1979 Sep;28(9):928-33. doi: 10.1016/0026-0495(79)90093-3.