尿液中N-τ-甲基组氨酸非骨骼肌来源的定量重要性。
Quantitative importance of non-skeletal-muscle sources of N tau-methylhistidine in urine.
作者信息
Millward D J, Bates P C, Grimble G K, Brown J G, Nathan M, Rennie M J
出版信息
Biochem J. 1980 Jul 15;190(1):225-8. doi: 10.1042/bj1900225.
Abstract
Direct measurement of N tau-methylhistidine turnover in skeletal muscle, skin and gastrointestinal muscle indicates that these three tissues contribute only 24.9, 6.8 and 9.8% of the total urinary excretion. Measurement of the decay rate of radioactively labelled N tau-methylhistidine in urine indicates that skeletal muscle accounts for 74.5% of the urinary excretion and this is probably an overestimate. These results suggest that the common assumption, that N tau-methylhistidine in urine originates almost entirely from skeletal muscle, may be wrong.
摘要
对骨骼肌、皮肤和胃肠道肌肉中N-τ-甲基组氨酸周转率的直接测量表明，这三种组织对尿中总排泄量的贡献分别仅为24.9%、6.8%和9.8%。对尿中放射性标记的N-τ-甲基组氨酸衰变率的测量表明，骨骼肌占尿排泄量的74.5%，而这可能是高估了。这些结果表明，尿中N-τ-甲基组氨酸几乎完全源自骨骼肌这一普遍假设可能是错误的。
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