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与医学相关节肢动物相关的过敏反应。

Allergic reactions associated with medically relevant arthropods.

机构信息

SaBio, Instituto de Investigación en Recursos Cinegéticos IREC-CSIC-UCLM-JCCM, Ciudad Real, Spain.

Medicine School, Universidad de Castilla la Mancha (UCLM), Ciudad Real, Spain.

出版信息

Ann Med. 2023;55(2):2286531. doi: 10.1080/07853890.2023.2286531. Epub 2023 Nov 27.

DOI:10.1080/07853890.2023.2286531
PMID:38010429
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10836243/
Abstract

OBJECTIVE

Vector-borne diseases are a growing burden worldwide. In particular, the risks of allergic reactions to bites are associated with growing arthropod populations in contact with the public. The diversity of allergic reactions associated with host and arthropod factors difficult disease diagnosis, prognosis and prevention. Therefore, arthropod-associated allergies are underdiagnosed and require better surveillance of arthropod populations and disease diagnosis and management.

METHODS

To face these challenges, in this study, we describe five cases to illustrate arthropod-associated allergies with different symptomatology, including alpha-gal syndrome (AGS) associated with anti-alpha-gal IgE antibody titres. Information on symptoms in response to arthropod bites was collected from patients and medical doctors.

RESULTS

The five cases included patients bitten by a robber fly and different tick species. Cases were in Spain or U.S.A. Two cases were diagnosed with AGS and one case was diagnosed with anaphylaxis in response to tick bite with high anti-alpha-gal IgE levels. The symptoms in response to arthropod bites vary between different cases.

CONCLUSION

Allergic reactions and symptoms in response to arthropod bites vary in association with host and arthropod factors. Herein we propose recommendations to control allergic symptoms, associated disease risk factors and the way forward to advance in the prevention and control of arthropod-associated allergies.

摘要

目的

虫媒病在全球范围内的负担日益加重。特别是，与公众接触的节肢动物种群不断增加，导致对叮咬的过敏反应风险增加。与宿主和节肢动物因素相关的过敏反应的多样性使得疾病的诊断、预后和预防变得困难。因此，与节肢动物相关的过敏反应被漏诊，需要更好地监测节肢动物种群以及疾病的诊断和管理。

方法

为了应对这些挑战，在本研究中，我们描述了五个病例，这些病例说明了具有不同症状的与节肢动物相关的过敏反应，包括与抗α-半乳糖 IgE 抗体滴度相关的α-半乳糖综合征（AGS）。从患者和医生那里收集了有关对节肢动物叮咬的症状信息。

结果

这五个病例包括被强盗蝇和不同种类的蜱叮咬的患者。病例发生在西班牙或美国。其中两例被诊断为 AGS，一例被诊断为因 tick bite 而产生的过敏反应，其抗α-半乳糖 IgE 水平较高。对节肢动物叮咬的反应症状在不同病例之间有所不同。

结论

与宿主和节肢动物因素相关，过敏反应和对节肢动物叮咬的症状各不相同。在此，我们提出了控制过敏症状、相关疾病风险因素以及推进预防和控制与节肢动物相关的过敏反应的建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/a8051f8ccd37/IANN_A_2286531_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/56b3a9a357b5/IANN_A_2286531_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/657d2c8fdc9b/IANN_A_2286531_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/f2c161668534/IANN_A_2286531_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/a8051f8ccd37/IANN_A_2286531_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/56b3a9a357b5/IANN_A_2286531_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/657d2c8fdc9b/IANN_A_2286531_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/f2c161668534/IANN_A_2286531_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b8/10836243/a8051f8ccd37/IANN_A_2286531_F0004_C.jpg

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Alpha-gal syndrome-Food or drug allergy: A case report.α-半乳糖综合征-食物或药物过敏：一例报告
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Comparison of acarological risk metrics derived from active and passive surveillance and their concordance with tick-borne disease incidence.
Curr Opin Allergy Clin Immunol. 2024 Oct 1;24(5):349-355. doi: 10.1097/ACI.0000000000001014. Epub 2024 Aug 2.
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Improving Surveillance of Human Tick-Borne Disease Risks: Spatial Analysis Using Multimodal Databases.提高人类蜱传疾病风险监测能力：利用多模态数据库进行空间分析。
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