卵巢储备功能降低与不孕妇女的代谢紊乱和高同型半胱氨酸血症有关。

Diminished ovarian reserve is associated with metabolic disturbances and hyperhomocysteinemia in women with infertility.

机构信息

Center for Reproductive Medicine of Shaoxing Women and Children's Hospital, Shaoxing, China.

出版信息

J Obstet Gynaecol. 2023 Dec;43(2):2282722. doi: 10.1080/01443615.2023.2282722. Epub 2023 Nov 27.

DOI:10.1080/01443615.2023.2282722

PMID:38010903

Abstract

BACKGROUND

To distinguish the metabolic profile between women with diminished ovarian reserve (DOR) and those with normal ovarian reserve (NOR).

METHODS

In this retrospective study, we enrolled 524 women under the age of 40 who were experiencing infertility: 261 in the DOR group and 263 in the NOR group. Physical characteristics and metabolic parameters were compared between these two groups.

RESULTS

Women with DOR exhibited a higher propensity for elevated parameters including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), as well as heightened serum levels of homocysteine (Hcy), triglycerides (TG), low-density lipoprotein (LDL), and triglyceride-glucose (TyG) index, while concurrently experiencing reduced serum levels of high-density lipoprotein (HDL) ( < 0.05). Furthermore, the incidence rates of TG ≥ 1.7 mmol/L, hyperhomocysteinemia (HHcy), BMI ≥ 25 kg/m, SBP/DBP ≥ 130/85 mmHg, and metabolic syndrome (MS) were significantly elevated within the DOR group as compared to the NOR group ( < 0.05).

CONCLUSION

The prevalence of metabolic disturbances and HHcy were notably elevated in women with infertility and DOR compared to those with NOR.

摘要

背景

为了区分卵巢储备功能减退（DOR）和正常卵巢储备（NOR）女性的代谢特征。

方法

本回顾性研究纳入了 524 名年龄在 40 岁以下的不孕女性：DOR 组 261 例，NOR 组 263 例。比较两组患者的一般特征和代谢参数。

结果

DOR 组的体重指数（BMI）、收缩压（SBP）、舒张压（DBP）、同型半胱氨酸（Hcy）、甘油三酯（TG）、低密度脂蛋白（LDL）和甘油三酯-葡萄糖（TyG）指数均高于 NOR 组，高密度脂蛋白（HDL）水平则低于 NOR 组（均<0.05）。此外，DOR 组的 TG≥1.7mmol/L、高同型半胱氨酸血症（HHcy）、BMI≥25kg/m²、SBP/DBP≥130/85mmHg 和代谢综合征（MS）的发生率明显高于 NOR 组（均<0.05）。