Brooks A M, Weiner J M, Robertson I F
Aust N Z J Ophthalmol. 1986 May;14(2):127-32. doi: 10.1111/j.1442-9071.1986.tb00023.x.
Untreated latent syphilis with interstitial keratitis is not uncommon in the older age group who may present with refractive problems. It is important to investigate these patients with a full range of serological tests for syphilis to determine whether they have been treated adequately in the past. If there is evidence of untreated latent syphilis, examination of the cerebrospinal fluid is important to exclude asymptomatic neurosyphilis for which intensive systemic therapy in hospital is indicated. If there is no evidence of central nervous system involvement a course of penicillin is still indicated, but may be given on an outpatient basis. This is illustrated by the histories of six patients who presented to The Royal Victorian Eye and Ear Hospital between 1962 and 1979.
伴有间质性角膜炎的未经治疗的潜伏梅毒在可能出现屈光问题的老年人群中并不少见。对这些患者进行全面的梅毒血清学检测以确定他们过去是否得到充分治疗非常重要。如果有未经治疗的潜伏梅毒证据，检查脑脊液对于排除无症状神经梅毒很重要，对于无症状神经梅毒需在医院进行强化全身治疗。如果没有中枢神经系统受累的证据，仍需使用青霉素治疗，但可以门诊治疗。1962年至1979年间在皇家维多利亚眼耳医院就诊的6例患者的病史说明了这一点。
