Department of General Surgery, Huai'an Fifth People's Hospital, Huai'an, Jiangsu, China.
Department of Pathology, Hen'an University, Kaifeng, He'nan, China.
Medicine (Baltimore). 2023 Nov 24;102(47):e36151. doi: 10.1097/MD.0000000000036151.
Primary synovial sarcoma of the prostate is an extremely rare mesenchymal malignant soft tissue tumor with unique morphological features. Synovial sarcoma often occurs in the pararticular tissues of limbs in young people, but rarely occurs in prostate. Because it is very rare, it is easily misdiagnosed as benign prostatic hyperplasia or prostate cancer clinically. A case of synchronous acinar adenocarcinoma of the prostate has not been reported. In this article, we report a unique case of primary prostatic synovial sarcoma with acinar adenocarcinoma.
A 58-year-old male patient was found to have a prostate mass during physical examination. Prostate ultrasound examination showed an increase in prostate volume of 5.2 × 3.3 × 3.3 cm, mixed echo mass can be seen on the left side of the prostate, with a size of approximately 4.9 × 4.3 cm, left seminal vesicle compressed.
Prostatic synovial sarcoma (biphasic type) combined with prostatic acinar adenocarcinoma (Gleason 3 + 3).
The patient received radical prostatectomy, followed by adjuvant chemotherapy and radiotherapy.
After 2 months of follow-up, at the time of writing this article, the patient received a comprehensive treatment plan of adjuvant chemotherapy and radiotherapy for 2 months, and no recurrence or metastasis was found.
Primary prostatic synovial sarcoma (biphasic type) combined with prostatic acinar adenocarcinoma is a very unique and rare case, and effective treatment guidelines are not yet clear, posing new challenges to clinical treatment. Making full use of pathological and imaging examinations, early diagnosis and radical surgery combined with multidisciplinary treatment seem to be still a positive method.
原发性前列腺滑膜肉瘤是一种极为罕见的具有独特形态特征的间叶性恶性软组织肿瘤。滑膜肉瘤常发生于年轻人四肢的关节旁组织，但在前列腺中很少见。由于其非常罕见，临床上易误诊为良性前列腺增生或前列腺癌。目前尚未报道同时发生的前列腺腺癌病例。本文报道了 1 例具有腺泡腺癌的原发性前列腺滑膜肉瘤的独特病例。
一名 58 岁男性患者在体检时发现前列腺肿块。前列腺超声检查显示前列腺体积增大至 5.2×3.3×3.3cm，前列腺左侧可见混合回声肿块，大小约为 4.9×4.3cm，左侧精囊受压。
前列腺滑膜肉瘤（双相型）合并前列腺腺泡腺癌（Gleason 评分 3+3）。
患者接受了根治性前列腺切除术，随后进行了辅助化疗和放疗。
随访 2 个月后，在撰写本文时，患者接受了 2 个月的辅助化疗和放疗综合治疗方案，未发现复发或转移。
原发性前列腺滑膜肉瘤（双相型）合并前列腺腺泡腺癌是一种非常独特和罕见的病例，目前还没有明确的有效治疗指南，这对临床治疗提出了新的挑战。充分利用病理和影像学检查，早期诊断和根治性手术结合多学科治疗似乎仍然是一种积极的方法。
