Yeagle P L, Sen A
Biochemistry. 1986 Nov 18;25(23):7518-22. doi: 10.1021/bi00371a039.
The effects of chaotropic agents on the lamellar to hexagonal II phase transition of soy phosphatidylethanolamine were examined. Guanidine hydrochloride, urea, and NaSCN were used as chaotropic agents. In each case, the lamellar phase was stabilized by the presence of the chaotropic agent. In the case of NaSCN, the temperature of the lamellar to hexagonal phase transition of soy phosphatidylethanolamine was increased by more than 60 degrees C. Guanidine hydrochloride was capable of substantially reducing the aggregation of phosphatidylethanolamine vesicles. These data lead to a thermodynamic understanding of the lamellar to hexagonal phase transition.
研究了离液剂对大豆磷脂酰乙醇胺从片层相到六方II相转变的影响。使用盐酸胍、尿素和硫氰酸钠作为离液剂。在每种情况下，离液剂的存在使片层相得以稳定。就硫氰酸钠而言，大豆磷脂酰乙醇胺从片层相到六方相转变的温度升高了60多摄氏度。盐酸胍能够显著减少磷脂酰乙醇胺囊泡的聚集。这些数据有助于从热力学角度理解片层相到六方相的转变。
