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Is Interleukin-6 blockade a viable strategy to prevent progression of acute respiratory distress syndrome in non-COVID viral pneumonia?

作者信息

Padappayil Rana Prathap, Yarrarapu Siva Naga S, Tiperneni Raghu, Li Boning

机构信息

Internal Medicine, Monmouth Medical Center, United States.

Pulmonary and Critical Care Medicine, Monmouth Medical Center, United States.

出版信息

Clin Immunol Commun. 2023 Dec;3:21-22. doi: 10.1016/j.clicom.2023.02.004. Epub 2023 Feb 10.

DOI:10.1016/j.clicom.2023.02.004
PMID:38014402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9912812/
Abstract
摘要

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J Investig Med. 2022 Jan;70(1):55-60. doi: 10.1136/jim-2021-002001. Epub 2021 Sep 24.
2
Dynamically linking influenza virus infection kinetics, lung injury, inflammation, and disease severity.动态关联流感病毒感染动力学、肺损伤、炎症和疾病严重程度。
Elife. 2021 Jul 20;10:e68864. doi: 10.7554/eLife.68864.
3
Interleukin-6 blocking agents for treating COVID-19: a living systematic review.白细胞介素 6 阻断剂治疗 COVID-19：一项实时系统评价。
Cochrane Database Syst Rev. 2021 Mar 18;3(3):CD013881. doi: 10.1002/14651858.CD013881.
4
Cytokine Storm.细胞因子风暴
N Engl J Med. 2020 Dec 3;383(23):2255-2273. doi: 10.1056/NEJMra2026131.
5
Influenza Virus-Induced Robust Expression of SOCS3 Contributes to Excessive Production of IL-6.流感病毒诱导 SOCS3 的强烈表达有助于过度产生 IL-6。
Front Immunol. 2019 Aug 16;10:1843. doi: 10.3389/fimmu.2019.01843. eCollection 2019.
6
The Role of Interleukin 6 During Viral Infections.白细胞介素6在病毒感染中的作用。
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Pathogenesis of influenza-induced acute respiratory distress syndrome.流感导致的急性呼吸窘迫综合征的发病机制。
Lancet Infect Dis. 2014 Jan;14(1):57-69. doi: 10.1016/S1473-3099(13)70286-X. Epub 2013 Nov 13.
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