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甲型 H1N1 流感病毒感染患儿白细胞介素-1β和白细胞介素-6 的上调。

IL-1 β and IL-6 upregulation in children with H1N1 influenza virus infection.

机构信息

Department of Pediatrics, Catholic University of the Sacred Heart, A. Gemelli Hospital, Policlinico Gemelli, Largo Gemelli, 1-00168 Rome, Italy.

出版信息

Mediators Inflamm. 2013;2013:495848. doi: 10.1155/2013/495848. Epub 2013 Apr 29.

DOI:10.1155/2013/495848
PMID:23737648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3657430/
Abstract

The role of cytokines in relation to clinical manifestations, disease severity, and outcome of children with H1N1 virus infection remains thus far unclear. The aim of this study was to evaluate interleukin IL-1 β and IL-6 plasma expressions and their association with clinical findings, disease severity, and outcome of children with H1N1 infection. We prospectively evaluated 15 children with H1N1 virus infection and 15 controls with lower respiratory tract infections (LRTI). Interleukin plasma levels were measured using immunoenzymatic assays. Significantly higher levels of IL-1 β and IL-6 were detected in all patients with H1N1 virus infection compared to controls. It is noteworthy to mention that in H1N1 patients with more severe clinical manifestations of disease IL-1 β and IL-6 expressions were significantly upregulated compared to H1N1 patients with mild clinical manifestations. In particular, IL-6 was significantly correlated with specific clinical findings, such as severity of respiratory compromise and fever. No correlation was found between interleukin expression and final outcome. In conclusion, H1N1 virus infection induces an early and significant upregulation of both interleukins IL1 β and IL-6 plasma expressions. The upregulation of these cytokines is likely to play a proinflammatory role in H1N1 virus infection and may contribute to airway inflammation and bronchial hyperreactivity in these patients.

摘要

细胞因子在 H1N1 病毒感染儿童的临床表现、疾病严重程度和预后中的作用尚不清楚。本研究旨在评估白细胞介素（IL）-1β和 IL-6 的血浆表达及其与 H1N1 感染患儿的临床发现、疾病严重程度和预后的关系。我们前瞻性评估了 15 例 H1N1 病毒感染患儿和 15 例下呼吸道感染（LRTI）对照组。采用免疫酶联测定法检测白细胞介素血浆水平。与对照组相比，所有 H1N1 病毒感染患者的 IL-1β和 IL-6 水平均显著升高。值得注意的是，与 H1N1 轻症患者相比，H1N1 重症患者的 IL-1β和 IL-6 表达显著上调。特别是，IL-6 与特定的临床发现，如呼吸窘迫的严重程度和发热，显著相关。白细胞介素表达与最终结局之间无相关性。总之，H1N1 病毒感染诱导白细胞介素（IL）-1β和 IL-6 血浆表达的早期和显著上调。这些细胞因子的上调可能在 H1N1 病毒感染中发挥促炎作用，并可能导致这些患者的气道炎症和支气管高反应性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/b9944266c85c/MI2013-495848.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/8f91de1101db/MI2013-495848.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/9e31b5f230b6/MI2013-495848.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/87a503d1f866/MI2013-495848.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/ef4a2490bbcf/MI2013-495848.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/2a50283e7d6b/MI2013-495848.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/b9944266c85c/MI2013-495848.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/8f91de1101db/MI2013-495848.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/9e31b5f230b6/MI2013-495848.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/87a503d1f866/MI2013-495848.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/ef4a2490bbcf/MI2013-495848.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/2a50283e7d6b/MI2013-495848.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d34c/3657430/b9944266c85c/MI2013-495848.006.jpg

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