Menopause. 2024 Jan 1;31(1):26-32. doi: 10.1097/GME.0000000000002283. Epub 2023 Nov 27.
Menarche and menopause are associated with muscle loss and strength in women. Handgrip strength (HGS) is a reliable measurement method of muscle strength. However, it is unclear whether the entire reproductive period, which encompasses both menarche and menopause, is associated with HGS in postmenopausal women.
A total of 2,354 postmenopausal women aged 45-75 years were included for statistical analysis. The reproductive period was divided into tertiles, and HGS was divided into four quartiles. HGS was measured to evaluate muscle strength. Binary logistic regression analysis was used to identify significant predictors with the first quartile HGS, derived from quartile data. Multiple logistic regression analysis was used to assess the relationship between the reproductive period (exposure) and low HGS (outcome).
We found that the more extended the reproductive period, the lower the risk of low absolute HGS. This trend persisted even after controlling for other variables. Specifically, the odds ratio for low absolute HGS was 0.752 (95% confidence interval [CI], 0.563-1.000) for the second tertile reproductive period and 0.683 (95% CI, 0.513-0.900) for the third tertile reproductive period, with the first tertile reproductive period as the reference. The odds ratio for low relative HGS was 0.761 (95% CI, 0.551-1.052) for the second tertile reproductive period and 0.732 (95% CI, 0.533-0.972) for the third tertile reproductive period, using first tertile reproductive period as the reference, after covariate adjustment.
A longer reproductive period is associated with a decreased risk of low HGS in postmenopausal women.
月经初潮和绝经与女性肌肉丧失和力量下降有关。握力（HGS）是肌肉力量的可靠测量方法。然而，尚不清楚整个生殖期（包括月经初潮和绝经）是否与绝经后女性的 HGS 相关。
共纳入 2354 名 45-75 岁的绝经后女性进行统计分析。将生殖期分为三分位，HGS 分为四分位。测量 HGS 以评估肌肉力量。使用二元逻辑回归分析确定第一四分位数 HGS 的显著预测因子，源自四分位数数据。使用多变量逻辑回归分析评估生殖期（暴露）与低 HGS（结局）之间的关系。
我们发现，生殖期越长，低绝对 HGS 的风险越低。即使控制了其他变量，这种趋势仍然存在。具体而言，第二三分位生殖期低绝对 HGS 的比值比为 0.752（95%置信区间 [CI]，0.563-1.000），第三三分位生殖期为 0.683（95%CI，0.513-0.900），第一三分位生殖期为参考。第二三分位生殖期低相对 HGS 的比值比为 0.761（95%CI，0.551-1.052），第三三分位生殖期为 0.732（95%CI，0.533-0.972），第一三分位生殖期为参考，在调整协变量后。
较长的生殖期与绝经后女性低 HGS 的风险降低相关。
