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[应激诱导的心肌线粒体与肌原纤维面积比或定量比的变化及其甲状腺激素的纠正作用]

[Stress-induced changes in the area ratio or the quantitative ratio of myocardial mitochondria and myofibrils and their correction with thyroid hormones].

作者信息

Bozhko A P, Sukhorukova T A, Archakova L I

出版信息

Biull Eksp Biol Med. 1987 Jan;103(1):27-30.

PMID:3801645
Abstract

An experimental study performed on 30 male white rats has demonstrated that immobilization stress was associated with a decrease in mitochondrial to myofibril area ratio (Smch/Smf) in the left ventricle and interventricular septum by 34.6% and 46.9%, respectively. Pretreatment with small doses of thyroid hormones which did not influence body weight, heart rhythm or serum thyroxin level prevented the decrease and caused Smch/Smf increase in the left ventricle and interventricular septum by 68.7% and 45.8%, respectively. The doses of thyroid hormones applied caused a more marked increase of mitochondrial to myofibril area ratio in the control rats.

摘要

对30只雄性白鼠进行的一项实验研究表明,制动应激与左心室和室间隔中线粒体与肌原纤维面积比(Smch/Smf)分别降低34.6%和46.9%相关。小剂量甲状腺激素预处理对体重、心律或血清甲状腺素水平无影响,但可防止这种降低,并使左心室和室间隔的Smch/Smf分别增加68.7%和45.8%。所应用的甲状腺激素剂量使对照大鼠的线粒体与肌原纤维面积比有更显著的增加。

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