Bielnik K, Szram S, Koktysz R
Department of Ultrastructural Pathology Military Medical School, Lódź.
Patol Pol. 1992;43(4):153-5.
The authors carried out morphometric analysis of the surface, area, circumference and shape of myofibrillar mitochondria in rats submitted for acute experimental intoxication with ethylene glycol. The measurements were taken at 12 and 24 hours after intoxication and compared with those in the control group. A significant increase in mitochondrial circumference and surface area was seen as early as 12 hours with their shape being more rounded than elongated. At 24 hours of the experiment the parameters further increased. The use of computer image analysis permitted an objective and measurable confirmation of changes in electronograms and revealed the presence of disorders in the phase in which traditional methods were useless.
作者对乙二醇急性实验性中毒大鼠的肌原纤维线粒体的表面、面积、周长和形状进行了形态计量分析。在中毒后12小时和24小时进行测量，并与对照组进行比较。早在中毒12小时就观察到线粒体周长和表面积显著增加，其形状更圆而非拉长。在实验24小时时，这些参数进一步增加。计算机图像分析的使用使得能够客观且可测量地确认电子图中的变化，并揭示了在传统方法无用的阶段存在的紊乱情况。
