Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Pathol Res Pract. 2023 Jul;247:154541. doi: 10.1016/j.prp.2023.154541. Epub 2023 May 18.
Over the past few decades, the application of mesenchymal stem cells has captured the attention of researchers and practitioners worldwide. These cells can be obtained from practically every tissue in the body and are used to treat a broad variety of conditions, most notably neurological diseases such as Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and Alzheimer's disease. Studies are still being conducted, and the results of these studies have led to the identification of several different molecular pathways involved in the neuroglial speciation process. These molecular systems are closely regulated and interconnected due to the coordinated efforts of many components that make up the machinery responsible for cell signaling. Within the scope of this study, we compared and contrasted the numerous mesenchymal cell sources and their cellular features. These many sources of mesenchymal cells included adipocyte cells, fetal umbilical cord tissue, and bone marrow. In addition, we investigated whether these cells can potentially treat and modify neurodegenerative illnesses.
在过去的几十年中，间充质干细胞的应用引起了全球研究人员和从业者的关注。这些细胞几乎可以从身体的每个组织中获得，用于治疗多种疾病，尤其是神经退行性疾病，如帕金森病、多发性硬化症、肌萎缩侧索硬化症和阿尔茨海默病。目前仍在进行研究，这些研究的结果确定了几种不同的分子途径，这些分子途径涉及神经胶质特化过程。由于负责细胞信号传递的许多成分的协调努力，这些分子系统受到紧密的调节和相互关联。在本研究中，我们比较和对比了许多间充质细胞来源及其细胞特征。这些间充质细胞的来源包括脂肪细胞、胎儿脐带组织和骨髓。此外，我们还研究了这些细胞是否有可能治疗和修饰神经退行性疾病。
