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肠道-关节轴通过肠道微生物群的代谢物介导 TNF 诱导的 RA 过程和 PBMT 治疗效果。

The gut-joint axis mediates the TNF-induced RA process and PBMT therapeutic effects through the metabolites of gut microbiota.

机构信息

Department of Microbiology, WU Lien-Teh Institute, Harbin Medical University, Harbin, China.

Heilongjiang Provincial Key Laboratory of Infection and Immunity, Harbin Medical University, Harbin, China.

出版信息

Gut Microbes. 2023 Dec;15(2):2281382. doi: 10.1080/19490976.2023.2281382. Epub 2023 Nov 28.

DOI:10.1080/19490976.2023.2281382
PMID:38017660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10730145/
Abstract

The gut-joint axis, one of the mechanisms that mediates the onset and progression of joint and related diseases through gut microbiota, and shows the potential as therapeutic target. A variety of drugs exert therapeutic effects on rheumatoid arthritis (RA) through the gut-joint axis. However, the anti-inflammatory and immunomodulatory effect of novel photobiomodulatory therapy (PBMT) on RA need further validation and the involvement of gut-joint axis in this process remains unknown. The present study demonstrated the beneficial effects of PBMT on RA, where we found the restoration of gut microbiota homeostasis, and the related key pathways and metabolites after PBMT. We also discovered that the therapeutic effects of PBMT on RA mainly through the gut-joint axis, in which the amino acid metabolites (Alanine and N-acetyl aspartate) play the key role and rely on the activity of metabolic enzymes in the target organs. Together, the results prove that the metabolites of amino acid from gut microbiota mediate the regulation effect on the gut-joint axis and the therapeutic effect on rheumatoid arthritis of PBMT.

摘要

肠道-关节轴是通过肠道微生物群介导关节及相关疾病发生和进展的机制之一，具有作为治疗靶点的潜力。多种药物通过肠道-关节轴对类风湿关节炎（RA）发挥治疗作用。然而，新型光生物调节疗法（PBMT）对 RA 的抗炎和免疫调节作用需要进一步验证，并且该过程中肠道-关节轴的参与尚不清楚。本研究证明了 PBMT 对 RA 的有益作用，我们发现 PBMT 后肠道微生物组稳态得到恢复，相关关键途径和代谢物也得到恢复。我们还发现，PBMT 对 RA 的治疗作用主要通过肠道-关节轴，其中氨基酸代谢物（丙氨酸和 N-乙酰天冬氨酸）发挥关键作用，并依赖于靶器官中代谢酶的活性。总之，这些结果证明了肠道微生物群的氨基酸代谢物介导了对肠道-关节轴的调节作用以及 PBMT 对类风湿关节炎的治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/9333101330ad/KGMI_A_2281382_F0009_OC.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/7b2a5aac3afb/KGMI_A_2281382_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/da87b5f13b16/KGMI_A_2281382_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/33d4becce498/KGMI_A_2281382_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/9333101330ad/KGMI_A_2281382_F0009_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/af0ff3f5acc5/KGMI_A_2281382_UF0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/daa9277ab9ec/KGMI_A_2281382_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/f8e93f653592/KGMI_A_2281382_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/67a53c825d44/KGMI_A_2281382_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/863f071bc6cf/KGMI_A_2281382_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/1e0e3275ee28/KGMI_A_2281382_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/7b2a5aac3afb/KGMI_A_2281382_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/da87b5f13b16/KGMI_A_2281382_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/33d4becce498/KGMI_A_2281382_F0008_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d5eb/10730145/9333101330ad/KGMI_A_2281382_F0009_OC.jpg

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