State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University , Guangzhou, China.
Guangzhou Laboratory , Guangzhou, China.
Microbiol Spectr. 2024 Jan 11;12(1):e0109023. doi: 10.1128/spectrum.01090-23. Epub 2023 Nov 29.
HAdV-3, -7, and -55 are the predominant types causing acute respiratory disease outbreaks and can lead to severe and fatal pneumonia in children and adults. In recent years, emerging or re-emerging strains of HAdV-7 and HAdV-55 have caused multiple outbreaks globally in both civilian and military populations, drawing increased attention. Clinical studies have reported that HAdV-7 and HAdV-55 cause more severe pneumonia than HAdV-3. This study aimed to investigate the mechanisms explaining the higher severity of HAdV-7 and HAdV-55 infection compared to HAdV-3 infection. Our findings provided evidence linking the receptor-binding protein fiber to stronger infectivity of the strains mentioned above by comparing several fiber-chimeric or fiber-replaced adenoviruses. Our study improves our understanding of adenovirus infection and highlights potential implications, including in novel vector and vaccine development.
HAdV-3、-7 和 -55 是引起急性呼吸道疾病暴发的主要类型，可导致儿童和成人发生严重和致命性肺炎。近年来，新兴或重现的 HAdV-7 和 HAdV-55 株已在平民和军人人群中引起多次全球暴发，引起了更多关注。临床研究报告称，HAdV-7 和 HAdV-55 引起的肺炎比 HAdV-3 更严重。本研究旨在探讨与 HAdV-3 感染相比，HAdV-7 和 HAdV-55 感染更严重的机制。我们的研究结果通过比较几种纤维嵌合或纤维替代的腺病毒，为受体结合蛋白纤维与上述菌株更强的感染性之间的联系提供了证据。本研究增进了我们对腺病毒感染的认识，并强调了其潜在意义，包括在新型载体和疫苗开发方面。
