Institut de Génétique Moléculaire de Montpellier, Université de Montpellier, CNRS, Montpellier, France.
PLoS Pathog. 2021 Sep 2;17(9):e1009814. doi: 10.1371/journal.ppat.1009814. eCollection 2021 Sep.
Many of us had refresher courses in virology, immunology, and epidemiology in 2020, and we were reminded of the fact that Homo sapiens, the wiliest predator on the planet, has been hunting everything that moves for millennia. These repeated interspecies contacts inherently lead to recurrent zoonosis (nonhuman to human) and anthroponosis (human to nonhuman). Given the accelerating changes in our ecosystems since the neolithic revolution, it was not surprising to see a virus that spreads via aerosolization and liquid droplets cause a pandemic in a few months. The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic begs the question-which viruses could cause a global threat? In this Opinion, the characteristics that make adenoviruses a risk, which include efficient intra- and interspecies transmission, thermostable particles, persistent/latent infections in diverse hosts, and the ability to readily recombine and escape herd immunity, are discussed.
在 2020 年，我们许多人都学习了病毒学、免疫学和流行病学的进修课程，我们也被提醒这样一个事实：智人是地球上最狡猾的掠食者，数千年来一直在捕猎一切有生命的东西。这些反复发生的种间接触必然导致反复出现的人畜共患病（非人类传染给人类）和人间传染病（人类传染给非人类）。考虑到自新石器时代革命以来我们的生态系统加速变化，一种通过气溶胶和液滴传播的病毒在短短几个月内引发大流行并不奇怪。严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）大流行引发了一个问题——哪些病毒可能构成全球威胁？在本观点中，讨论了使腺病毒成为一种风险的特征，包括高效的种内和种间传播、耐热颗粒、在各种宿主中持续/潜伏感染，以及易于重组和逃避群体免疫的能力。
