Global Health Research Center, Duke Kunshan University, Kunshan, China.
Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
BMC Infect Dis. 2021 Aug 3;21(1):748. doi: 10.1186/s12879-021-06412-0.
Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs).
To understand the epidemiology and subtype distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV subtypes.
HAdV was successfully sequenced in 99 (2.4%) of the 4129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%), and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer.
All ages suffer adenovirus infections, but young children are at the greatest risk. This study data demonstrates that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.
人类腺病毒（HAdVs）可引起各年龄段人群的多种疾病。它们尤其会导致儿童频繁发病。在中国，自 2000 年以来，人类腺病毒 3、4、7、11、14、21 和 55 型至少已引发 7 次暴发。然而，关于呼吸道感染（RTIs）住院患者中 HAdV 型的流行病学模式和多样性，相关研究仍十分有限。
为了解中国 RTIs 相关 HAdV 感染的流行病学特征和亚型分布，我们收集了 2017 年 8 月至 2019 年 10 月广州某医院 4129 例鼻拭子（NS）临床样本。对这些标本进行 PCR、测序和系统进化分析，以鉴定 HAdV 亚型。
我们成功对 4129 例 NS 标本中的 99 例（2.4%）进行了 HAdV 测序，发现 5 至 10 岁儿童的 HAdV 阳性率最高（6.3%）。在 HAdV 阳性标本中，最常见的基因型是 HAdV-B3（55.6%）和 HAdV-B7（25.3%）。HAdV 感染患者最常见的症状是发热（100%）、咳嗽（80.8%）和流涕（71.8%）。HAdV 全年均可检测到，夏季阳性率相对较高。
所有年龄段的人都可能感染腺病毒，但幼儿面临的风险最大。本研究数据表明，至少有三种 HAdV 型（B、C 和 E 种）在中国广州市流行。随着抗病毒疗法和型特异性疫苗的出现，此类流行病学数据将有助于指导治疗和公共卫生干预。
