Chen Yuewei, Zhou Yanyan, Hu Zihe, Lu Weiying, Li Zhuang, Gao Ning, Liu Nian, Li Yuanrong, He Jing, Gao Qing, Xie Zhijian, Li Jiachun, He Yong
State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, Hangzhou, 310027, People's Republic of China.
School of Mechanical Engineering, Guizhou University, Guiyang, 550025, People's Republic of China.
Nanomicro Lett. 2023 Nov 29;16(1):34. doi: 10.1007/s40820-023-01225-z.
Implantable hydrogel-based bioelectronics (IHB) can precisely monitor human health and diagnose diseases. However, achieving biodegradability, biocompatibility, and high conformality with soft tissues poses significant challenges for IHB. Gelatin is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most tissues. This study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film (GCF) with mechanical programmability. The regulation of GCF nearly covers soft tissue mechanics, an elastic modulus from 20 to 420 kPa, and a Poisson's ratio from - 0.25 to 0.52. The negative Poisson's ratio promotes conformality with soft tissues to improve the efficiency of biological interfaces. The GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high conformability. Notably, the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue restoration. The GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.
基于水凝胶的可植入生物电子器件（IHB）能够精确监测人体健康并诊断疾病。然而，实现生物可降解性、生物相容性以及与软组织的高贴合性对IHB构成了重大挑战。明胶是IHB最合适的候选材料，因为它是一种胶原蛋白水解产物，也是大多数组织中天然存在的细胞外基质的重要组成部分。本研究采用具有超材料设计的3D打印超细纤维网络嵌入超低弹性模量水凝胶中，以制造一种具有机械可编程性的新型明胶基导电膜（GCF）。GCF的调节范围几乎涵盖了软组织力学性能，弹性模量从20到420千帕，泊松比从 -0.25到0.52。负泊松比促进了与软组织的贴合性，从而提高了生物界面的效率。由于其高贴合性，GCF能够通过确定心脏变形来监测心跳信号和呼吸频率。值得注意的是，可生物降解GCF的明胶特性使传感器能够监测并支持组织修复。GCF超材料设计为生物电子学开发集成监测和组织修复功能的可植入传感器提供了独特思路，也为赋予植入式传感器与软组织高度贴合性提供了一种定制方法。
