Curran Aoife, Toma Ahmed, Watkins Laurence, Darie Lucia
Medical student at University College Dublin, Ireland.
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, University College Hospitals London, United Kingdom.
Brain Spine. 2023 Nov 9;3:102709. doi: 10.1016/j.bas.2023.102709. eCollection 2023.
Limited information is available regarding the direct effect of drugs prescribed to elevate intracranial pressure (ICP) in contrast to the abundance of evidence in support of medication utilized to lower ICP. Theophylline is a methylxanthine derivate used in the treatment of respiratory diseases with only a few randomized control trials or case reports describing pain improvement in low CSF pressure states or spontaneous intracranial hypotension (SIH). We present the case of a recorded increase in intracranial pressure under theophylline.
A 23-year-old female with a complex history of hydrocephalus and syringomyelia was experiencing debilitating symptoms due to refractory intracranial hypotension. Medical management with oral theophylline was attempted for a period of three months. Intracranial pressure measurements were obtained via the telemetric pressure sensor reservoir (Miethke®, M.scio®) incorporated in the patient's ventriculoperitoneal shunt system.
A significant increase in intracranial pressure was recorded at therapeutic drug levels.
This is the first report of an increase in intracranial pressure under oral theophylline medication.
与大量支持用于降低颅内压（ICP）的药物的证据相比，关于用于升高ICP的药物的直接作用的信息有限。茶碱是一种甲基黄嘌呤衍生物，用于治疗呼吸系统疾病，仅有少数随机对照试验或病例报告描述了其在低脑脊液压力状态或自发性颅内低压（SIH）中改善疼痛的情况。我们报告了一例在使用茶碱期间颅内压升高的病例。
一名23岁女性，有脑积水和脊髓空洞症的复杂病史，因难治性颅内低压而出现衰弱症状。尝试口服茶碱进行药物治疗，为期三个月。通过患者脑室腹腔分流系统中内置的遥测压力传感器储液器（Miethke®，M.scio®）测量颅内压。
在治疗药物水平时记录到颅内压显著升高。
这是第一例关于口服茶碱药物导致颅内压升高的报告。
