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女性生殖道同步黏液化生及肿瘤伴尿道外口肿瘤：一例报告

Synchronous mucinous metaplasia and neoplasia of the female genital tract with external urethral meatus neoplasm: A case report.

作者信息

Ikeda Yuji, Yasuda Masanori, Kato Tomomi, Yano Yuri, Kurosaki Akira, Hasegawa Kosei

机构信息

Department of Gynecologic Oncology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.

Department of Pathology, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama 350-1298, Japan.

出版信息

Gynecol Oncol Rep. 2015 Feb 17;12:27-30. doi: 10.1016/j.gore.2015.02.001. eCollection 2015 Apr.

DOI:10.1016/j.gore.2015.02.001
PMID:26076154
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4442654/
Abstract

•We present a case of multiple mucinous metaplasia and neoplasia of cervix, endometrium, fallopian tube, ovary, and mesenterium with external urethral meatus neoplasm.•Immunohistochemistry showed almost same pattern in each neoplasms.•PCR-direct sequencing showed no existence of both KRAS and GNAS mutations.•This report suggests a possibility of synchronous mucinous metaplasia and neoplasia "beyond" female genital tract.

摘要

•我们报告一例宫颈、子宫内膜、输卵管、卵巢和肠系膜多发黏液化生及肿瘤形成，并伴有尿道外口肿瘤。

•免疫组织化学显示各肿瘤的模式几乎相同。

•聚合酶链反应直接测序显示KRAS和GNAS均无突变。

•本报告提示存在女性生殖道以外同步黏液化生及肿瘤形成的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/0d3f3263dfc7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/f9c414456ce8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/625dc01e4b52/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/0d3f3263dfc7/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/f9c414456ce8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/625dc01e4b52/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c9/4442654/0d3f3263dfc7/gr3.jpg

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本文引用的文献

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Hereditary gynecological tumors associated with Peutz-Jeghers syndrome (Review).与黑斑息肉综合征相关的遗传性妇科肿瘤（综述）
Oncol Lett. 2013 Nov;6(5):1184-1188. doi: 10.3892/ol.2013.1527. Epub 2013 Aug 16.
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子宫内膜乳头状黏液性化生可能是子宫内膜黏液性腺癌的前驱病变。
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Reappraisal of synchronous and multifocal mucinous lesions of the female genital tract: a close association with gastric metaplasia.女性生殖道同步性和多灶性黏液性病变的重新评估：与胃化生密切相关。
Histopathology. 2009 Jan;54(2):184-91. doi: 10.1111/j.1365-2559.2008.03202.x.
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An unusual admixture of neoplastic and metaplastic lesions of the female genital tract in the Peutz-Jeghers Syndrome.黑斑息肉综合征中女性生殖道肿瘤性与化生性病损的一种罕见混合情况。
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Nature. 1989 Aug 31;340(6236):692-6. doi: 10.1038/340692a0.